The effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine” on Ehrlich ascites carcinoma in mice
Hassan, M., Ali, H., Salah El Dien, W., Amer, A. (2020). The effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine” on Ehrlich ascites carcinoma in mice. EKB Journal Management System, 16(1), 90-100. doi: 10.21608/blj.2020.146595
Mohamed E.A. Hassan; Haytham A Ali; Waiel M. Salah El Dien; Atef M. Amer. "The effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine” on Ehrlich ascites carcinoma in mice". EKB Journal Management System, 16, 1, 2020, 90-100. doi: 10.21608/blj.2020.146595
Hassan, M., Ali, H., Salah El Dien, W., Amer, A. (2020). 'The effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine” on Ehrlich ascites carcinoma in mice', EKB Journal Management System, 16(1), pp. 90-100. doi: 10.21608/blj.2020.146595
Hassan, M., Ali, H., Salah El Dien, W., Amer, A. The effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine” on Ehrlich ascites carcinoma in mice. EKB Journal Management System, 2020; 16(1): 90-100. doi: 10.21608/blj.2020.146595

The effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine” on Ehrlich ascites carcinoma in mice

Biochemistry Letters
Article 7, Volume 16, Issue 1, 2020, Page 90-100  XML PDF (615.33 K)
Document Type: Original Article
DOI: 10.21608/blj.2020.146595
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Authors
Mohamed E.A. Hassan1; Haytham A Ali2; Waiel M. Salah El Dien3; Atef M. Amer4
1Department of bioChemistry, Faculty of Science, Zagazig University, Egypt
2Department Biochemistry Faculty of Vet medicine Zagazig University
3Animal Health Research Institute, Zagazig Prov.Lab., Dep.of Food Hygiene
4Department of Chemistry, Faculty of Science, Zagazig University, Egypt
Abstract
Pyrazolopyridine derivatives are organic substance with novel properties. They have many beneficial uses as antibacterial and antifungal etc; so this study was designed to investigate the antitumor and hepatoprotective effect of "3, 6 diamino-5-cyano-4-(p-chloro phenyl) - Pyrazolo [3, 4- b] pyridine" in comparison to folfox (5-flouro uracil 50 mg/kg &6mg/kg oxaloplatine). Thirty five adult male mice (24-26 g) was divided into five groups (7 each).first one considered as a negative control, second as positive control, third and fourth treated intraperitoneal with 35 mg/kg B.WT. Of compound from the 1st day and after one week of EAC injected respectively. Serum analysis of liver enzymes showed a significant increase in ALT, AST and significant decrease in serum Albumin and total protein activity, also there were an elevation in inflammatory gene expression of cytokine TNF-alpha and insignificant elevation in gene expression of CDKn2D. and after treatment, the liver function showed normal level and significant decreases of gene expression of cytokine TNF-alpha. In addition, gene expression of CDKn2D showed significant elevation in it is level           .         
Keywords
pyrazolopyridine derivatives; Ehrlich ascites carcinoma in mice; liver enzymes; TNF-alpha; CDKn2D
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