Association between AXIN1 gene polymorphisms (wnt signaling pathway gene) and nephropathy induced by diabetes and hypertension in the Egyptian population
Said, N., Moustafa, H., Abdel Aziz, S. (2020). Association between AXIN1 gene polymorphisms (wnt signaling pathway gene) and nephropathy induced by diabetes and hypertension in the Egyptian population. EKB Journal Management System, 16(1), 128-150. doi: 10.21608/blj.2020.146611
Noha Mohamed Said; Hamed Yousef Moustafa; Samah Abdel Aziz. "Association between AXIN1 gene polymorphisms (wnt signaling pathway gene) and nephropathy induced by diabetes and hypertension in the Egyptian population". EKB Journal Management System, 16, 1, 2020, 128-150. doi: 10.21608/blj.2020.146611
Said, N., Moustafa, H., Abdel Aziz, S. (2020). 'Association between AXIN1 gene polymorphisms (wnt signaling pathway gene) and nephropathy induced by diabetes and hypertension in the Egyptian population', EKB Journal Management System, 16(1), pp. 128-150. doi: 10.21608/blj.2020.146611
Said, N., Moustafa, H., Abdel Aziz, S. Association between AXIN1 gene polymorphisms (wnt signaling pathway gene) and nephropathy induced by diabetes and hypertension in the Egyptian population. EKB Journal Management System, 2020; 16(1): 128-150. doi: 10.21608/blj.2020.146611

Association between AXIN1 gene polymorphisms (wnt signaling pathway gene) and nephropathy induced by diabetes and hypertension in the Egyptian population

Biochemistry Letters
Article 11, Volume 16, Issue 1, 2020, Page 128-150  XML PDF (532.5 K)
Document Type: Original Article
DOI: 10.21608/blj.2020.146611
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Authors
Noha Mohamed Said1; Hamed Yousef Moustafa2; Samah Abdel Aziz1
1Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
Abstract
Background: Chronic renal disease is a public health concern worldwide. The epidemiology of this disease can help in the protection strategy. The detection of the polymorphism of the CKD candidate gene can assist in the early detection Chronic. And thus, early detection and treatment can often avoid or postpone the kidney disease. Objectives: Our research aimed to investigate how polymorphisms of the AXIN-1 gene and CKD incidence are associated with Egyptians. Methods: This study included 3 groups; control group, a pre-nephropathy group including (diabetes 2 and hypertension) subgroups, and a nephropathy group including (diabetic nephropathy, hypertensive nephropathy, and diabetic hypertensive nephropathy) subgroups. All the volunteers are subjected to complete clinical examination and routine laboratory analysis.  In this research, we performed genotyping for two SNPs (rs9921222 and rs1805105) throughout the Egyptian population (PCR-RFLP). Results: our results showed that in both (rs9921222 and rs1805105) SNPs, there was a significant difference in genotypes distribution (P<0.001) Conclusion: The AXIN-1 SNPs (rs9921222 and rs1805105) may be used as one of the Egyptian population's CKD susceptibility factors and larger studies can confirm our results.
Keywords
CKD AXIN; 1 gene PCR; RFLP Egyptian population
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