MALONDIALDEHYDE IN TYPE 2 DIABETICS AND ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS | ||||
| Journal of the Medical Research Institute | ||||
| Article 1, Volume 41, Issue 2, December 2020, Page 21-30 PDF (930 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmalexu.2020.147116 | ||||
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| Authors | ||||
| M. Shalash1; M. Badra1; S. Imbaby2; E. ElBanna3 | ||||
| 1Department of Internal Medicine , Faculty of Medicine, Alexandria University, Egypt. | ||||
| 2Department of Chemical and Clinical pathology, Faculty of Medicine, Alexandria University, Egypt. | ||||
| 3Department of MBBCH, Alexandria University. | ||||
| Abstract | ||||
| Background: Type 2 diabetes mellitus (T2DM) is a progressive chronic disease with high prevalence all over the world. It is expected to have 693 million people affected by diabetes by 2045. Many body systems are affected due to complications of DM with major effect on the cardiovascular system. Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Malondialdehyde (MDA) is a highly toxic end product formed by lipid oxidation that mediates its toxic effects due to its high reactivity particularly towards proteins and DNA. Malondialdehyde interacts both irreversibly and reversibly with proteins and phospholipids causing profound effects, especially in the collagen of the cardiovascular system. Normally, MDA level remains within normal values due to antioxidant effects, but in DM these protective effects are disrupted. Objective: Measure serum Malondialdehyde level as a marker of lipid peroxidation in type 2 diabetic patients and its association with other cardiovascular risk factors. Patients and methods: The study included 40 diabetic patients recruited from Outpatient Diabetes Clinic at Alexandria Main University Hospital in addition to healthy 40 healthy subjects as a control group. Basic data, clinical examination and laboratory analysis were obtained from all the subjects within the two groups. Serum Malondialdehyde (MDA) was measured in the participants within the two groups by using ELISA kit. Results: The mean serum MDA level was statistically significant higher in the diabetic cases as compared to the controls (Median MDA was 30.72nmol /ml in cases and 25.16 nmol /ml in the control). There is a significant increase in serum MDA level with increasing the risk of CV disease in the whole study subjects and in the diabetic cases. In the cases group MDA shows positive correlation with all the study parameters except high density lipoproteins (HDL) where it revealed negative correlation. BY ROC curve analysis, a cutoff point more than > 26.57 had 62.5% sensitivity, 70% specificity, 66.4 % positive predictive value (PPV) and 72.5% negative predictive value (NPV). Conclusion: Malondialdehyde is a non-invasive biomarker that could be utilized in differentiation of T2DM cases form healthy controls in addition for identifying the high-risk diabetic patients for cardiovascular disease (CVD). However, further large-scale studies are recommended to accurately determine its sensitivity and specificity. | ||||
| Keywords | ||||
| Malondialdehyde; lipid peroxidation; oxidative stress; cardiovascular diseases | ||||
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