Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.
Aziz, A., raoof, S., Hasan, W., Saied, S. (2021). Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.. EKB Journal Management System, 64(5), 2405-2413. doi: 10.21608/ejchem.2021.54383.3130
ammar A Aziz; samaa adnan raoof; waseem M Hasan; Shakir Mahmood Saied. "Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.". EKB Journal Management System, 64, 5, 2021, 2405-2413. doi: 10.21608/ejchem.2021.54383.3130
Aziz, A., raoof, S., Hasan, W., Saied, S. (2021). 'Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.', EKB Journal Management System, 64(5), pp. 2405-2413. doi: 10.21608/ejchem.2021.54383.3130
Aziz, A., raoof, S., Hasan, W., Saied, S. Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.. EKB Journal Management System, 2021; 64(5): 2405-2413. doi: 10.21608/ejchem.2021.54383.3130

Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.

Egyptian Journal of Chemistry
Article 17, Volume 64, Issue 5, May 2021, Page 2405-2413  XML PDF (659.61 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2021.54383.3130
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Authors
ammar A Aziz1; samaa adnan raoof email orcid 2; waseem M Hasan3; Shakir Mahmood Saied4
1Northern Technical University
2Northren Technical University
3Al-noor University College
4Al-Noor University College, Mosul
Abstract
Abstract:
New complexes with a mixture of aspirin (acetylsalicylic acid ) with methyldopa or paracetamol with methyldopa were synthesized via the reflux of reaction mixture using a basic medium to deprotonate the ligands.
These new complexes of Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) with a mixture of aspirin (acetylsalicylic acid ), paracetamol and methyldopa have characterized using FTIR , UV-visible spectra, magnetic susceptibility, flame atomic absorption, C.H.N.S analysis and melting points measurements.
The two mixed ligands have been found to act as bidentate chelating agents. Aspirin (acetylsalicylic acid) complexes coordinate to the metal ions through the oxygen of Aspirin's ester group and oxygen of the carboxyl group, while Methyldopa as ligand is coordinated through the oxygen of the hydroxyl group and the nitrogen of the amide groups. The Paracetamol was coordinated through the oxygen atom of carboxyl group and the nitrogen atom of the amide group.
The stability of these new complexes depends on the size of the chelate rings, thus these ligands with a flexible organic backbone and their complexes contain five and six membered chelate rings, which have almost no strain. The molar conductance measurements for the metal complexes show non-electrolytic behavior in DMF solvent.
The all synthesized complexes which show non-electrolytic properties, also were no conducting electrical current behaved as bi-dentate with octahedral geometrical isomers.
Keywords
Aspirin (acetylsalicylic acid ); Paracetamol; Methyldopa; IR; UV; Spectrum of flame
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