Role of Tomato Extract in Protection against Damage Caused by Mesenteric Ischemia/ Reperfusion Induced in γ-Irradiated Rats | ||||
| Egyptian Journal of Radiation Sciences and Applications | ||||
| Article 6, Volume 24, Issue 2, December 2011, Page 285-295 PDF (405.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrsa.2011.1474 | ||||
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| Abstract | ||||
| THE OBJECTIVE is, the protective effects of turmeric (Tur) as well as tomato extract (TE) against whole γ-irradiation injury of rats subjected to mesenteric ischemia/reperfusion (I/R). Male Wistar rats were divided into shame and irradiated groups. Normal group subjected to sham-operation. Vitamin E (VE) treated-group served as a positive control. Ileal tissue samples were obtained to investigate glutathione (GSH), thiobarbituric reactive substances (TBARS), nitrite contents as well as activity of lactate dehydrogenase (LDH). In addition, cytokines; tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were measured. Intestinal I/R injury revealed a marked depletion in GSH, elevated TBARS and nitrite contents as well as low LDH activity. Moreover, there were remarkable increases in measured cytokines (TNF-α&IL-6). The ischemic insults were exacerbated by acute γ-irradiation in most of measured parameters except for GSH and LDH activity. In I/R treated-groups, TE could restore GSH contents and LDH (cell membrane integrity) as compared with VE with no lipid peroxidation protection. However, both supplements corrected levels of nitrite and TNF-α. Either Tur or TE could correct most of biochemical changes in irradiated rats. In general, both supplements recorded antioxidant and anti-inflammatory effects upon irradiation. | ||||
| Keywords | ||||
| Intestine; Oxidative Stress; Radiotherapy; ischemia; Cytokines; Turmeric; Tomato | ||||
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