Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article
Ellisy, R., Bakri, A., Mangoura, S., Abdelraheem, M., Farghaly, H. (2022). Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article. EKB Journal Management System, 5(2), 355-361. doi: 10.21608/svuijm.2021.60196.1070
Reham A.M. Ellisy; Ali Helmi Bakri; Safwat A. Mangoura; Mahmoud H. Abdelraheem; Hanan S.M. Farghaly. "Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article". EKB Journal Management System, 5, 2, 2022, 355-361. doi: 10.21608/svuijm.2021.60196.1070
Ellisy, R., Bakri, A., Mangoura, S., Abdelraheem, M., Farghaly, H. (2022). 'Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article', EKB Journal Management System, 5(2), pp. 355-361. doi: 10.21608/svuijm.2021.60196.1070
Ellisy, R., Bakri, A., Mangoura, S., Abdelraheem, M., Farghaly, H. Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article. EKB Journal Management System, 2022; 5(2): 355-361. doi: 10.21608/svuijm.2021.60196.1070

Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article

SVU-International Journal of Medical Sciences
Article 35, Volume 5, Issue 2, July 2022, Page 355-361  XML PDF (195.4 K)
Document Type: Reviews Articles.
DOI: 10.21608/svuijm.2021.60196.1070
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Authors
Reham A.M. Ellisy email 1; Ali Helmi Bakri2; Safwat A. Mangoura3; Mahmoud H. Abdelraheem3; Hanan S.M. Farghaly3
1Medical Pharmacology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
2Pediatric Department , Faculty of Medicine, South Valley University, Qena, Egypt
3Medical Pharmacology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abstract
Background: Valproic acid is an important anticonvulsant and mood-stabilizing drug. It is also used in the therapy of bipolar disorders, migraine, cancer and neurodegenerative disorders. The use of valproate in epileptic disorders depends on trial and error with fluctuation of the prescribed dose until the patient is controlled with the least effective dose without side effects. With the emergence of pharmacogenomics, it is important to know the genes regulating valproic acid signaling pathways, related transporters, receptor mutations, pharmacokinetics, pharmacodynamics and adverse drug reactions. Thereafter, we can use valproic acid with more efficacy and tolerability. Highlight the genetic variations associated with valproic acid mechanism of action, pharmacokinetics, pharmacodynamics and side effects.We have searched literatures in PubMed, google scholar,Egyptian bank of knowledge and science direct.
Conclusion: There are several candidate genes affecting valproic acid efficacy, tolerability and safety. Therefore, we can prescribe the right valproic dose to the right patient at the right time, thus, allowing optimization of valproic acid therapy.
Keywords
Genetic variants; pharmacogenetics; polymorphism; valproic acid
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