Value of magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) in predicting grade of soft tissue sarcoma
Assy, M., Refaat, M., salem, A. (2022). Value of magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) in predicting grade of soft tissue sarcoma. EKB Journal Management System, 28(3), 389-400. doi: 10.21608/zumj.2021.57296.2076
Mostafa Mohamad Assy; Mona Mohammed Refaat; ahmed fekry salem. "Value of magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) in predicting grade of soft tissue sarcoma". EKB Journal Management System, 28, 3, 2022, 389-400. doi: 10.21608/zumj.2021.57296.2076
Assy, M., Refaat, M., salem, A. (2022). 'Value of magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) in predicting grade of soft tissue sarcoma', EKB Journal Management System, 28(3), pp. 389-400. doi: 10.21608/zumj.2021.57296.2076
Assy, M., Refaat, M., salem, A. Value of magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) in predicting grade of soft tissue sarcoma. EKB Journal Management System, 2022; 28(3): 389-400. doi: 10.21608/zumj.2021.57296.2076

Value of magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) in predicting grade of soft tissue sarcoma

Zagazig University Medical Journal
Article 1, Volume 28, Issue 3, May 2022, Page 389-400  XML PDF (767.54 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.57296.2076
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Authors
Mostafa Mohamad Assyorcid 1; Mona Mohammed Refaat2; ahmed fekry salem email orcid 3
1Department od Radiodiagnosis, Zagazig University, Zagazig, Egypt
2radiodiagnosis,faculty of medicine,zagazig university,egypt
3Department of Radiodiagnosis, Zagazig University, Zagazig, Egypt
Abstract
Objectives: To identify the predictive values of MRI features and apparent diffusion coefficient (ADC) measurements that can be used to discriminate high-grade from low grade soft-tissue sarcoma (STS). Patients and methods: In this retrospective research, patients with different histologic grades of STS diagnosed between 2018 and 2020 who had undergone MRI examination and DWI before neo-adjuvant treatment or surgery were included. STS grades (grades 1–3) were recorded from the pathologic specimens and images were evaluated for tumour location, depth, size and characteristic MRI features discriminating low-grade lesions (grade 1 and 2) from high-grade ones (grades 3). Results: Fifty two patients; 29 (55.7%) men and 23 (44.3 %) women with STS, 24 patients with low-grade and 28 patients with high-grade were included. The commonest pathologic type was undifferentiated pleomorphic sarcoma (n = 14), with the majority of tumors 32/52 (61.5%) were in lower extremities. There were three main MRI findings related more to high grade STS: Presence of area compatible with necrosis, tumor margins < 50 % definition and peri-tumoral enhancement, in addition to the ADC mean which was significantly lower in high-grade (0.921±0.308) than in low-grades tumors (1.24±0.414); (p = 0.0006). Conclusion: Our research appraises the conventional MRI findings of tumor margin definitions, amount of necrosis, and peri-tumoral enhancement in addition to ADC measurements in grading of STS with significant reliability to offer predictive data and support clinical decision making.
Keywords
MRI; DWI; ADC; Sarcoma; Tumor grade
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