Possible Role of γ-Irradiated Ginseng in the Modulation of Some Biochemical Disorders Produced by Aluminum in Rats | ||||
| Egyptian Journal of Radiation Sciences and Applications | ||||
| Article 13, Volume 24, Issue 2, December 2011, Page 373-385 PDF (435.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrsa.2011.1482 | ||||
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| Abstract | ||||
| ALUMINUM (Al) toxicity in human and animals has been a matter of concern. Ginseng is liable to be contaminated by micro-organisms during the pre- and post-harvest handlings. Thus, ginseng decontamination by γ- rays is needed to warrant the microbiological quality. The aim of this study is to demonstrate the protective effect of γ-irradiated ginseng against Al-induced toxicity in rat model. Male albino rats were divided into four groups of 8 rats : A control group, the γ- irradiated ginseng extract (IGE) group; daily received the IGE (400 mg kg-1 body wt) for 6 weeks, the Al group received orally a daily dose (0.5 mg kg-1 body wt) of aluminum chloride (AlCl3) for 6 weeks and the irradiated ginseng extract+ AlCl3 (IGE-Al) group, received IGE+ AlCl3 for 6 weeks. Al administration significantly decreased some haematological parameters, sex hormones. Antioxidant enzymes activity in liver and testes showed a decrease. The results also showed a significant increase in some hepatic marker enzymes associated with an elevation of tissue lipid peroxidation (LPO). When experimental animals received IGE+ ALCL3, all these parameters were restored to approximately the control levels. These results demonstrated that administration of γ-irradiated ginseng could be effective in the protection against the toxicity of AlCl3. | ||||
| Keywords | ||||
| Aluminum; Ginseng; Radiation; Oxidative Stress; antioxidants | ||||
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