Early Initiation of Gn RH Antagonist versus long agonist Protocols in PCOS Patients Undergoing ICSI Cycles.
El-Azab, S., Emam, M., Youssef, H., El-Shazly, A., Abou-Hashem, E. (2014). Early Initiation of Gn RH Antagonist versus long agonist Protocols in PCOS Patients Undergoing ICSI Cycles.. EKB Journal Management System, 1(1), 71-79. doi: 10.21608/mnj.2014.149005
Sameh El-Azab; Mohammad Emam; Hamed Youssef; Abu-El-Hasan El-Shazly; Ekbal Abou-Hashem. "Early Initiation of Gn RH Antagonist versus long agonist Protocols in PCOS Patients Undergoing ICSI Cycles.". EKB Journal Management System, 1, 1, 2014, 71-79. doi: 10.21608/mnj.2014.149005
El-Azab, S., Emam, M., Youssef, H., El-Shazly, A., Abou-Hashem, E. (2014). 'Early Initiation of Gn RH Antagonist versus long agonist Protocols in PCOS Patients Undergoing ICSI Cycles.', EKB Journal Management System, 1(1), pp. 71-79. doi: 10.21608/mnj.2014.149005
El-Azab, S., Emam, M., Youssef, H., El-Shazly, A., Abou-Hashem, E. Early Initiation of Gn RH Antagonist versus long agonist Protocols in PCOS Patients Undergoing ICSI Cycles.. EKB Journal Management System, 2014; 1(1): 71-79. doi: 10.21608/mnj.2014.149005

Early Initiation of Gn RH Antagonist versus long agonist Protocols in PCOS Patients Undergoing ICSI Cycles.

Mansoura Nursing Journal
Article 7, Volume 1, Issue 1, January 2014, Page 71-79  XML PDF (291.93 K)
Document Type: Original Article
DOI: 10.21608/mnj.2014.149005
View on SCiNiTO View on SCiNiTO
Authors
Sameh El-Azab* 1; Mohammad Emam1; Hamed Youssef1; Abu-El-Hasan El-Shazly1; Ekbal Abou-Hashem2
1Department of Obstetrics and Gynecology, Faculty of Medicine ,Mansoura University
2Department of Clinical Pathology , Faculty of Medicine, Mansoura University,
Abstract
Abstract
Purpose: To compare the efficacy of early initiation of Gonadotrophin Releasing Hormone (GnRH) antagonist in comparison with the GnRH agonist protocol in Polycystic Ovarian Syndrome (PCOS) patients undergoing Intracytoplasmic Sperm Injection (ICSI) cycles. Materials and methods: Prospective randomized controlled trial. Seventy infertile PCOS patients under 35 years of age coming for the first trial IVF/ICSI treatment at the infertility care unit were included in the study. They were randomized to either GnRH agonist long protocol (control group A) or early initiation of GnRh antagonist (study group B) after pretreatment with OCP. Ovulation was triggered with Humman Chorionic Gonadotrophin (hCG) when at least 3 mature follicles 18 mm were detected. Results: Age, body mass index, duration of infertility, basal Follicle Stimulating Hormone (FSH), Lutinizing Hormone (LH), Estradiol (E2) at the first day of the cycle, the number of oocytes retrived, the total number of embryos, chemical, clinical pregnancy and implantation rates were comparable in both groups and there was no statistically significant difference. The stimulation period was shorter in group B than group A and number of ampoules of gonadotrophins ampoules and Serum E2 level on the day of hCG administration were significantly lower in group B than that of the group A with statistically significant differences. Moderate OHSS was documented in 4 cycles of group A but was not in any cycle of group B and this difference was statistically significant. No cases of severe OHSS were documented in both groups.Conclusions: This novel antagonist protocol may be a safe and efficient treatment for PCOS patients undergoing ICSI cycles with comparable results to the standard long GnRH agonist protocol.
Keywords
PCOS; ICSI; Gonadotrophin Releasing Hormone (GnRH) antagonist
Statistics
Article View: 70
PDF Download: 111