Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat
B N, H., A S, A., N A, A., M E, H. (2015). Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat. EKB Journal Management System, 61(1), 570-574. doi: 10.12816/0018761
Hassan B N; Alazzouni A S; Al Jalaud N A; Hassan M E. "Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat". EKB Journal Management System, 61, 1, 2015, 570-574. doi: 10.12816/0018761
B N, H., A S, A., N A, A., M E, H. (2015). 'Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat', EKB Journal Management System, 61(1), pp. 570-574. doi: 10.12816/0018761
B N, H., A S, A., N A, A., M E, H. Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat. EKB Journal Management System, 2015; 61(1): 570-574. doi: 10.12816/0018761

Histological and Immunohistochemical Study on the Effect of Bisphenol A on the Retina of Female Albino Rat

The Egyptian Journal of Hospital Medicine
Article 34, Volume 61, Issue 1, October 2015, Page 570-574  XML PDF (727.8 K)
Document Type: Original Article
DOI: 10.12816/0018761
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Authors
Hassan B N1; Alazzouni A S1; Al Jalaud N A2; Hassan M E3
1Department of Zoology, Faculty of Science, Helwan University
2Department of Biology, Faculty of Science, Dammam University, Saudi Arabia
3Department of Ophthalmology, Faculty of Medicine, Al Azhar University
Abstract
Background: Bisphenol A (BPA) is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. Exposure of rats to low doses of BPA results in histopathological effects in their retina.
Objectives: We used histological and immunohistlogical techniques for determining retina pathological changes in response to low doses of BPA and the modulating effect of both vitamin A and stem enhancer.
Methods: Twenty female albino rats orally administered with 20mg BPA /kgb.wt/day for 45 days and then divided to groups and treated with vitamin A and stem enhancer. Both eyes were examined histologically and immunohistochemicaly to determine the histopathological changes in retinal layers.
Results: A remarkable degenerative histopathological changes in the ganglion cell layer and inner nuclear layer appeared with bis phenol treated rats and a clear improvement was seen after treatment with both vitamin A and stem cell enhancer.
Conclusions: Both of vitamin A and stem enhancer have ameliorative effect on the degenerative changes in the retinal layers and damaged estrogen receptors by the action of bisphenol A.  
 
Keywords
Estrogen; Anti estrogen receptor – BPA; retina
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