The Relation between Plasma Complement 4 d and Lupus Nephritis at Zagazig University Hospitals | ||||
Zagazig University Medical Journal | ||||
Article 21, Volume 28, Issue 4, July 2022, Page 778-783 PDF (363.19 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2021.57612.2077 | ||||
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Authors | ||||
Sara M Sakr 1; Adlia M Abdelhady2; Nahla Zidan3; Lobna I Kotb4 | ||||
1Rheumatology department at zagazig university | ||||
2Rheumatology,Rehabilitation and Physical medicine department,Faculty of medicine, Zagazig University | ||||
3Clinical Pathology Department, Faculty of Medicine,Zagazig University, Zagazig, Egypt | ||||
4Rheumatology,Rehabilitation and physical medicine department,Zagazig University | ||||
Abstract | ||||
Lupus nephritis is a common and serious manifestation of systemic lupus erythematosus,its diagnosis is established by a combination of clinical ,laboratory, serological data and histology of the kidney. Plasma complement 4 d can be used to predict flare of lupus nephritis. Aim: The aim of our work was to assess the relation between plasma complement 4 d and lupus nephritis.. Methods: This study was carried out on 100 Lupus Nephritis patients fulfilled the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and 100 apparently healthy age & sex matched controls. Plasma complement 4 d was detected by specific sandwich ELISA according to the instruction of the manufacturer (SunRed, Shanghi). Results: Our work showed that 24 hour urine protein,RBCs in urine, serum albumin, pus in urine were (significantly associated) with plasma C4d (unstandardized β=0.001, -0.213, 0.441, 0.041 and 0.024 respectively) (p < 0.05). Our results also revealed that there was statistically significant relations between plasma c4d and lupus nephritis in SLE patients (p < 0.05). Conclusion: The study evaluated the importance of Plasma complement 4d in lupus nephritis and confirmed that plasma complement 4d can be used as a very good marker of the flare of lupus nephritis. | ||||
Keywords | ||||
Systemic Lupus Erythematosis; Lupus nephritis; Complement 4 d | ||||
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