Intravenous Thrombolysis with rt-PA in Patients with Acute Ischemic Stroke: Experience of Al-Azhar University Hospitals and Almaadi Military Hospital Stroke Units
Mohamed, N., Nemr, A., Elghareeb, H., Abed, E. (2018). Intravenous Thrombolysis with rt-PA in Patients with Acute Ischemic Stroke: Experience of Al-Azhar University Hospitals and Almaadi Military Hospital Stroke Units. EKB Journal Management System, 73(4), 6412-6416. doi: 10.21608/ejhm.2018.15102
Nabil H Mohamed; Ahmed A Nemr; Hussein A Elghareeb; Elsayed E Abed. "Intravenous Thrombolysis with rt-PA in Patients with Acute Ischemic Stroke: Experience of Al-Azhar University Hospitals and Almaadi Military Hospital Stroke Units". EKB Journal Management System, 73, 4, 2018, 6412-6416. doi: 10.21608/ejhm.2018.15102
Mohamed, N., Nemr, A., Elghareeb, H., Abed, E. (2018). 'Intravenous Thrombolysis with rt-PA in Patients with Acute Ischemic Stroke: Experience of Al-Azhar University Hospitals and Almaadi Military Hospital Stroke Units', EKB Journal Management System, 73(4), pp. 6412-6416. doi: 10.21608/ejhm.2018.15102
Mohamed, N., Nemr, A., Elghareeb, H., Abed, E. Intravenous Thrombolysis with rt-PA in Patients with Acute Ischemic Stroke: Experience of Al-Azhar University Hospitals and Almaadi Military Hospital Stroke Units. EKB Journal Management System, 2018; 73(4): 6412-6416. doi: 10.21608/ejhm.2018.15102

Intravenous Thrombolysis with rt-PA in Patients with Acute Ischemic Stroke: Experience of Al-Azhar University Hospitals and Almaadi Military Hospital Stroke Units

The Egyptian Journal of Hospital Medicine
Article 6, Volume 73, Issue 4, October 2018, Page 6412-6416  XML PDF (424.43 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.15102
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Authors
Nabil H Mohamed1; Ahmed A Nemr2; Hussein A Elghareeb1; Elsayed E Abed email 1
1Departments of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Departments of Neurology, Military Medical Academy, Cairo, Egypt
Abstract
Background: Ischemic stroke (IS) is defined as a focal neurologic deficit of sudden onset and of presumed ischemic origin that lasts at least 24 hours and is not associated with hemorrhage on computed tomography (CT) or magnetic resonance imaging (MRI) of the brain. About 87% of strokes are ischemic, the rest being hemorrhagic. Bleeding can develop inside areas of ischemia, a condition known as "hemorrhagic transformation" (HT). Definitive therapy within the first few hours is aimed to removing the blockage by breaking the clot down (thrombolysis), or by removing it mechanically (thrombectomy). Aim of the Work: was to correlate the safety of recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke (AIS) patients in Egypt. Subjects and Methods: A number of case series of patients with AIS who were treated at Stroke Units of Al-Azhar University Hospitals and Almaadi Military Hospital over a period of 1years within a time window were reported. Results: we observed a statistically significant correlation between AIS patients who were treated by thrombolysis in time window and vascular risk factors and many important infrastructure-logistic factors. Conclusions: It could be concluded that thrombolytic therapy is a good standard treatment in time window but many barriers in developing countries were found. 
Keywords
Ischemic stroke; Time Window; rt-PA
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