The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats
Emam, N., Fadladdeen, K. (2016). The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats. EKB Journal Management System, 65(1), 611-626. doi: 10.12816/0033773
Nahed Mohamed Mansour Emam; Khadija Abdul jalil Fadladdeen. "The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats". EKB Journal Management System, 65, 1, 2016, 611-626. doi: 10.12816/0033773
Emam, N., Fadladdeen, K. (2016). 'The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats', EKB Journal Management System, 65(1), pp. 611-626. doi: 10.12816/0033773
Emam, N., Fadladdeen, K. The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats. EKB Journal Management System, 2016; 65(1): 611-626. doi: 10.12816/0033773

The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats

The Egyptian Journal of Hospital Medicine
Article 18, Volume 65, Issue 1, October 2016, Page 611-626  XML PDF (1.33 MB)
Document Type: Original Article
DOI: 10.12816/0033773
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Authors
Nahed Mohamed Mansour Emam email 1; Khadija Abdul jalil Fadladdeen2
1Faculty of Sciences, Al- Arish University, Egypt
2Faculty of Science, University of King Abdel-Aziz University, Saudi Arabia
Abstract
Aim of the work: this study aimed to examine the histological and histochemical changes in the skin tissue of male rats after exposure to gamma radiation and the possible therapeutic effect of either olive leaf extract or bone marrow mesenchymal stem cells.
Material and methods: the present study was applied on forty adult male albino rats (Sprague Dawely strain). The rats were categorized equally into five groups (1-C group: control rats; 2- O group: rats treated with plant leaves extract (15 mg/kg b. wt. /daily);  3-R group: rats exposed to a single dose of gamma-radiation (3 Gy); 4-RO group: rats of this group treated with olive leaf extract 15 mg /kg b.wt./daily one week prior to irradiation and one week post irradiation; 5- RS group: rats of this group were irradiated with 3Gy then treated with bone marrow mesenchymal stem cells (3×106 cells / ml suspension) through the caudal vein about 5 hours post radiation exposure. Histopathological and some common histochemical changes were studied.
Results: rats exposed to gamma radiation showed several histological and histochemical changes, these changes were improved by using either olive extract or bone marrow mesenchymal stem cells. The bone marrow mesenchymal stem cells (BMSCs) showed more obvious curative effect than olive leaf extract.
Conclusion: the present work showed that both olive leaf extract and bone marrow mesenchymal stem cells have skin tissue radiotherapeutic effects against gamma radiation in male albino rats.
 
Keywords
γ-radiation; albino rats; skin; bone marrow mesenchymal stem cells (BMSCs)–Histopathology- Histochemistry
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