SERUM LEVELS OF SOLUBLE FMS –LIKE TYROSINE KINASE -1 IN PRE-ECLAMPTIC AND ECLAMPTIC CASES AND ITS CORRELATION TO FETOMATERNAL OUTCOME
Khalil, M. (2021). SERUM LEVELS OF SOLUBLE FMS –LIKE TYROSINE KINASE -1 IN PRE-ECLAMPTIC AND ECLAMPTIC CASES AND ITS CORRELATION TO FETOMATERNAL OUTCOME. EKB Journal Management System, 3(2), 9-10. doi: 10.21608/alexpo.2021.63856.1124
Merihan Mahmoud Khalil. "SERUM LEVELS OF SOLUBLE FMS –LIKE TYROSINE KINASE -1 IN PRE-ECLAMPTIC AND ECLAMPTIC CASES AND ITS CORRELATION TO FETOMATERNAL OUTCOME". EKB Journal Management System, 3, 2, 2021, 9-10. doi: 10.21608/alexpo.2021.63856.1124
Khalil, M. (2021). 'SERUM LEVELS OF SOLUBLE FMS –LIKE TYROSINE KINASE -1 IN PRE-ECLAMPTIC AND ECLAMPTIC CASES AND ITS CORRELATION TO FETOMATERNAL OUTCOME', EKB Journal Management System, 3(2), pp. 9-10. doi: 10.21608/alexpo.2021.63856.1124
Khalil, M. SERUM LEVELS OF SOLUBLE FMS –LIKE TYROSINE KINASE -1 IN PRE-ECLAMPTIC AND ECLAMPTIC CASES AND ITS CORRELATION TO FETOMATERNAL OUTCOME. EKB Journal Management System, 2021; 3(2): 9-10. doi: 10.21608/alexpo.2021.63856.1124

SERUM LEVELS OF SOLUBLE FMS –LIKE TYROSINE KINASE -1 IN PRE-ECLAMPTIC AND ECLAMPTIC CASES AND ITS CORRELATION TO FETOMATERNAL OUTCOME

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Article 83, Volume 3, Issue 2, June 2021, Page 9-10  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2021.63856.1124
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Author
Merihan Mahmoud Khalil email
Department of Obstetrics and Gynecology, Shatby Maternity Hospital, Faculty of Medicine, Alexandria University, Egypt
Abstract
Preeclampsia is a multisystem progressive disorder characterized by the new onset of hypertension and proteinuria or the new onset of hypertension and significant end-organ dysfunction with or without proteinuria after 20 weeks of gestation or postpartum in previously normotensive women. It is develops due to placental and maternal vascular dysfunction and disappears after delivery gradually by time. The incidence is estimated to be between 3 and 10% of all pregnancies.
Maternal endothelial dysfunction which leads to pre-eclamptic signs and symptoms is induced by high levels of the antiangiogenic factor sFLT1, which is produced in the placenta and released into the maternal circulation. sFLT1 is a soluble splice variant of the membrane-bound receptor VEGFR1 that binds to the proangiogenic proteins VEGF and placental growth factor (PlGF); therefore, sFLT1 acts as a ligand trap and antagonizes ligand-mediated angiogenic signalling via the cell surface receptors.
Aim of the work
The aim of this work was to evaluate serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) in cases of severe preeclampsia and eclamptic fits,and to correlate serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) in these cases to outcome of fetus and mother and incidence of complication.
Keywords
antiangiogenic factor sFLT1; significantly increased in severe preeclampsia; cutoff point to predict eclamptic fits >11588.74pg/dl
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