Sex Hormone-Binding Globulin in Obese Type 2 Diabetics
Abd EL Salam, E., Mohamed, N., Maghraby, H., Mohamed, R. (2016). Sex Hormone-Binding Globulin in Obese Type 2 Diabetics. EKB Journal Management System, 65(1), 627-633. doi: 10.12816/0033774
Eman M Abd EL Salam; Nagwa A Mohamed; Hend M Maghraby; Rehab A Mohamed. "Sex Hormone-Binding Globulin in Obese Type 2 Diabetics". EKB Journal Management System, 65, 1, 2016, 627-633. doi: 10.12816/0033774
Abd EL Salam, E., Mohamed, N., Maghraby, H., Mohamed, R. (2016). 'Sex Hormone-Binding Globulin in Obese Type 2 Diabetics', EKB Journal Management System, 65(1), pp. 627-633. doi: 10.12816/0033774
Abd EL Salam, E., Mohamed, N., Maghraby, H., Mohamed, R. Sex Hormone-Binding Globulin in Obese Type 2 Diabetics. EKB Journal Management System, 2016; 65(1): 627-633. doi: 10.12816/0033774

Sex Hormone-Binding Globulin in Obese Type 2 Diabetics

The Egyptian Journal of Hospital Medicine
Article 19, Volume 65, Issue 1, October 2016, Page 627-633  XML PDF (310.85 K)
Document Type: Original Article
DOI: 10.12816/0033774
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Authors
Eman M Abd EL Salam1; Nagwa A Mohamed2; Hend M Maghraby3; Rehab A Mohamed3
1Internal Medicine Departments, Faculty of medicine, Al Azhar University, Cairo, Egypt
2Department of Clinical and Chemical Pathology, National Research Center, Cairo, Egypt
3Internal Medicine Departments, Faculty of medicine, Al Azhar University, Cairo, Egypt.
Abstract
Background: Obesity is one of risk factors for type 2 diabetes because of its association with insulin resistance and poor glycemic control. Sex hormone–binding globulin (SHBG) and adipose tissue hormones have a role in development of insulin resistance, hyperlipidemia and type 2 diabetes. Serum SHBG has a role in glucose homeostasis and low levels are associated with development of diabetes, cardiovascular diseases, insulin resistance and hyperinsulinemia. Aim of  work: to study the relationship between serum SHBG, obesity, and metabolic parameters in type 2 diabetes in both sex.
Patients and Methods: forty obese type 2 diabetic patients and ten obese non-diabetic as controls were included in this study. Blood was taking from all subjects for estimation of glucose, Lipid profile, insulin and SHBG. Results: there was highly significant decrease in mean serum SHBG concentration in diabetic group compared with control non diabetic group. There were significant negative associations between serum SHBG and age, disease duration, BMI and glucose. On the other hand, there were non significant correlations between SHBG and waist circumference, fasting insulin, HOMA-IR, cholesterol and triglyceride levels.
Conclusion: Low serum SHBG is associated with hyperglycemia in both sexes, independent of insulinemia
 
Keywords
SHBG; Type 2 Diabetes; Insulin; Obesity
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