BSA Binding Studies of Co(II), Ni(II) and Cu(II) Metal Complexes of Schiff base Derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole
Chaurasia, M., Tomar, D., Chandra, S. (2019). BSA Binding Studies of Co(II), Ni(II) and Cu(II) Metal Complexes of Schiff base Derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole. EKB Journal Management System, 62(2), 357-372. doi: 10.21608/ejchem.2018.4907.1434
Madhuri Chaurasia; Deepak Tomar; Sulekh Chandra. "BSA Binding Studies of Co(II), Ni(II) and Cu(II) Metal Complexes of Schiff base Derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole". EKB Journal Management System, 62, 2, 2019, 357-372. doi: 10.21608/ejchem.2018.4907.1434
Chaurasia, M., Tomar, D., Chandra, S. (2019). 'BSA Binding Studies of Co(II), Ni(II) and Cu(II) Metal Complexes of Schiff base Derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole', EKB Journal Management System, 62(2), pp. 357-372. doi: 10.21608/ejchem.2018.4907.1434
Chaurasia, M., Tomar, D., Chandra, S. BSA Binding Studies of Co(II), Ni(II) and Cu(II) Metal Complexes of Schiff base Derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole. EKB Journal Management System, 2019; 62(2): 357-372. doi: 10.21608/ejchem.2018.4907.1434

BSA Binding Studies of Co(II), Ni(II) and Cu(II) Metal Complexes of Schiff base Derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole

Egyptian Journal of Chemistry
Article 14, Volume 62, Issue 2, February 2019, Page 357-372  XML PDF (2.44 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.4907.1434
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Authors
Madhuri Chaurasia1; Deepak Tomar1; Sulekh Chandra email orcid 2
1Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN-Marg, New Delhi-110002, India
2Department of Chemistry, Zakir Husain Delhi College, University of Delhi, New Delhi-110001, India
Abstract
The synthesis of Schiff base HL has been done by taking an equimolar ratio of 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole. Ligand HL has been characterized by elemental analysis, IR, 1H NMR, 13C NMR and ESI-mass spectrometry. The metal complexes 1-6 have been synthesized by the reaction of ligand HL with hydrated Co(II), Ni(II) and Cu(II) chlorides in ethanol, in the ligand to metal molar ratio 1:1 and 2:1. The synthesized metal complexes 1-6 were characterized by elemental analysis, molar conductance, electronic spectra, IR, UV-visible and EPR spectra. TGA has been done to check the thermal stablity of ligand as well as metal complexes. Spectral data reveals that the ligand HL acts as uninegative bidentate for all metal complexes. The geometries of metal complexes 1-6 have been given on the basis of spectroscopic studies and optimized by density functional theory. The fluorescence techniques have been used to study the interactions of metal complexes towards bovine serum albumin (BSA). The results revealed that the fluorescence static quenching of BSA by metal complexes 1-6 and entropy driven hydrophobic interactions has been seen which could be useful for further drug design.
Keywords
Schiff base; Metal complexes; TGA; BSA binding
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