Effect of Bisphenol A on the First Generation of Female Rats from Both Parents Treated with the Same Xenoestrogen
Helal, E., Mustafa, M., Taha, N. (2016). Effect of Bisphenol A on the First Generation of Female Rats from Both Parents Treated with the Same Xenoestrogen. EKB Journal Management System, 64(1), 389-394. doi: 10.12816/0029030
Eman G. E. Helal; Mohamed A. Mustafa; Neama M. Taha. "Effect of Bisphenol A on the First Generation of Female Rats from Both Parents Treated with the Same Xenoestrogen". EKB Journal Management System, 64, 1, 2016, 389-394. doi: 10.12816/0029030
Helal, E., Mustafa, M., Taha, N. (2016). 'Effect of Bisphenol A on the First Generation of Female Rats from Both Parents Treated with the Same Xenoestrogen', EKB Journal Management System, 64(1), pp. 389-394. doi: 10.12816/0029030
Helal, E., Mustafa, M., Taha, N. Effect of Bisphenol A on the First Generation of Female Rats from Both Parents Treated with the Same Xenoestrogen. EKB Journal Management System, 2016; 64(1): 389-394. doi: 10.12816/0029030

Effect of Bisphenol A on the First Generation of Female Rats from Both Parents Treated with the Same Xenoestrogen

The Egyptian Journal of Hospital Medicine
Article 13, Volume 64, Issue 1, July 2016, Page 389-394  XML PDF (224.56 K)
Document Type: Original Article
DOI: 10.12816/0029030
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Authors
Eman G. E. Helal1; Mohamed A. Mustafa2; Neama M. Taha3
1Zoology Department, Faculty of Science, Al-Azhar University, Egypt
2Basic Centre of Science, Misr University for Science and Technology, Egypt
3Physiology Department, College of Medicine, Umm Al-Qura University, KSA
Abstract
Background: bisphenol A (BPA) is a worldwide used endocrine disruptor that is incorporated in many plastic industries. The exposure of human to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of such substances. The aim of the present work was to evaluate the extent to which BPA can affect the first generation (of parents treated with the same compound, during pregnancy and lactation), which treated with the same compound during their life time.
Materials and Methods: group 1: 15 control female rats. Group 2: 15 female rats of the first generation treated with BPA (20mg/kg b.wt) for one month. Sexual hormones, liver and kidney functions were measured.
Results: BPA induced increase in breast and ovarian tumor markers. It also showed significant increase in estrogen, FSH, prolactin, and progesterone. It is also increased liver function, kidney function, lipid profile. In the same time it leads to decrease in LH, HDL, and protein levels.
Conclusion: BPA induced toxicity, which is mediated by oxidative stress. This study ringing the bells of danger for using such compounds.
 
 
Keywords
BPA; Female; Rats; Liver; kidney; tumour marker; Generation; lipids
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