The Protective Role of Ginkgo Biloba against Radiation Induced Injury on Rat Gastro-intestinal Tract | ||||
| Egyptian Journal of Radiation Sciences and Applications | ||||
| Article 1, Volume 28, Issue 1, December 2015, Page 1-16 PDF (682.48 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrsa.2015.1516 | ||||
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| Abstract | ||||
| GINKGO BILOBA extract (EGb 761) is an antioxidant substance exhibits a wide variety of biological activities. The present study was performed to evaluate oxidative stress and inflammatory parameters of gastrointestinal injury induced by exposing rats to acute doses of γ-rays and the potential value of EGb 761 in preventing changes in these parameters. Male albino rats were treated orally with the extract in a dose of 100 mg/ kg for 7 successive days before whole body exposure to acute radiation levels of 2 and 6 Gray (Gy). Control groups were run concurrently. The rats were sacrificed 3 days after irradiation. Various inflammatory mediators and biochemical parameters were determined in the stomach and intestine. Both tissues were also examined histopathologically. Exposure to radiation led to dose dependent changes in the level of oxidative stress biomarkers (elevation of thiobarbituric acid reactive substance (TBARS) and nitrite associated with a glutathione (GSH) decrease as well as in the level of inflammatory parameters (elevation of Tumour necrosis factor-ὰ (TNF-ὰ) and myeloperoxidase (MPO) associated with depletion of prostaglandin E2 (PGE2). Pre-treatment with EGb 761 protected against the changes in both oxidative stress biomarkers and inflammatory mediators. EGb 761 exerted a protective effect against the radiation induced gastrointestinal damage, possibly through its anti-inflammatory and anti-oxidant properties. | ||||
| Keywords | ||||
| γ-rays; Oxidative Stress; Inflammatory mediators; Stomach; Intestine; Ginkgo biloba | ||||
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