Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode
Gahlan, A., Derayea, S., Omar, M., Saleh, G., Haredy, A. (2021). Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode. EKB Journal Management System, 64(6), 3121-3130. doi: 10.21608/ejchem.2021.48845.2999
Ahmed Abdelmogod Gahlan; Sayed Mohamed Derayea; Mahmoud Ahmed Omar; Gamal Ahmed Saleh; Ahmed Mogahed Haredy. "Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode". EKB Journal Management System, 64, 6, 2021, 3121-3130. doi: 10.21608/ejchem.2021.48845.2999
Gahlan, A., Derayea, S., Omar, M., Saleh, G., Haredy, A. (2021). 'Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode', EKB Journal Management System, 64(6), pp. 3121-3130. doi: 10.21608/ejchem.2021.48845.2999
Gahlan, A., Derayea, S., Omar, M., Saleh, G., Haredy, A. Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode. EKB Journal Management System, 2021; 64(6): 3121-3130. doi: 10.21608/ejchem.2021.48845.2999

Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode

Egyptian Journal of Chemistry
Article 43, Volume 64, Issue 6, June 2021, Page 3121-3130  XML PDF (804.35 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.48845.2999
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Authors
Ahmed Abdelmogod Gahlanorcid 1; Sayed Mohamed Derayeaorcid 2; Mahmoud Ahmed Omar3; Gamal Ahmed Saleh4; Ahmed Mogahed Haredy email orcid 2
1Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt
2Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt
3Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Minia
4Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
A new simple, cheap, and rapid method to increase the sensitivity of pencil graphite electrode (PGE) to determine Linagliptin (LNG) was developed by modified PGE with copper microparticles (Cu-PGE). The disposable modified sensor electrode's preparation depended on the electrodeposition of Cu-microparticles on the PGE that can be applied for determined LNG by complexed it with Cu+2 ions and measure the LNG-Cu complex onto the Cu-PGE improved. The preparation of this modified electrode is easy, simple, and cheap, and has high sensitivity. The modified electrode detected the LNG in the LNG-Cu complex range from 47.25 - 283.53 ng mL-1 with detection and quantitative limits of 6.0 and 20.0 ng mL-1, respectively, with a correlation coefficient of 0.9995. The proposed method was applied with success to determined LNG in the dosage form, spiked urine, and spiked plasma samples; additionally, the obtained modified electrode was put in comparison with the reported electrodes.
Keywords
Square Wave Anodic Voltammetric; Linagliptin; Microparticles Copper Pencil Graphite Electrode; Dosage Form and Biological Fluids
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