Biochemical and immunocytochemical studies of the testicular alteration caused by Amitriptyline in adult male rat | ||||
| Journal of Bioscience and Applied Research | ||||
| Article 6, Volume 4, Issue 4, December 2018, Page 418-424 PDF (678.52 K) | ||||
| DOI: 10.21608/jbaar.2018.152508 | ||||
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| Authors | ||||
Ehab Tousson  ; Somia Zaki; Ezar Hafez; Amani Gad
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| Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt | ||||
| Abstract | ||||
| Amitriptyline is one of the first reference tricyclic antidepressants (TCAs) with sedative and analgesic properties. This study aimed to investigate the testicular indices that influenced by amitriptyline treatment and examined it by biochemical, histological and Immunohistochemical methods. A total of 20 male albino rats were equally divided into two groups: the first was control and the second was amitriptyline intoxicated group. The results of this study showed that amitriptyline consumption significant decrease hormones parameters, increase sperms abnormalities, decrease sperm numbers, induced testicular tissue damage and P53 alterations. | ||||
| Keywords | ||||
| Amitriptyline; Antidepressant; reproductive hormones; testis; sexual dysfunction | ||||
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