Effect of the newly synthesized Pyrazole, And Pyrazolo Pyrimidine derivatives on Pythium Aphanidermatum (Edson) Fitzp
Moustafa, S., Elkanzi, N. (2021). Effect of the newly synthesized Pyrazole, And Pyrazolo Pyrimidine derivatives on Pythium Aphanidermatum (Edson) Fitzp. EKB Journal Management System, 64(6), 2857-2872. doi: 10.21608/ejchem.2021.29933.2643
Shaima Mohamed Nabil Moustafa; Nadia Ali Ahmed Elkanzi. "Effect of the newly synthesized Pyrazole, And Pyrazolo Pyrimidine derivatives on Pythium Aphanidermatum (Edson) Fitzp". EKB Journal Management System, 64, 6, 2021, 2857-2872. doi: 10.21608/ejchem.2021.29933.2643
Moustafa, S., Elkanzi, N. (2021). 'Effect of the newly synthesized Pyrazole, And Pyrazolo Pyrimidine derivatives on Pythium Aphanidermatum (Edson) Fitzp', EKB Journal Management System, 64(6), pp. 2857-2872. doi: 10.21608/ejchem.2021.29933.2643
Moustafa, S., Elkanzi, N. Effect of the newly synthesized Pyrazole, And Pyrazolo Pyrimidine derivatives on Pythium Aphanidermatum (Edson) Fitzp. EKB Journal Management System, 2021; 64(6): 2857-2872. doi: 10.21608/ejchem.2021.29933.2643

Effect of the newly synthesized Pyrazole, And Pyrazolo Pyrimidine derivatives on Pythium Aphanidermatum (Edson) Fitzp

Egyptian Journal of Chemistry
Article 14, Volume 64, Issue 6, June 2021, Page 2857-2872  XML PDF (1.63 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.29933.2643
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Authors
Shaima Mohamed Nabil Moustafa email orcid 1, 2; Nadia Ali Ahmed Elkanzi3, 4
1Botany Department, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia
2Department of Botany and Microbiology, Faculty of Science, El-Minia University, 61511, Egypt.
3Chemistry Department, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia.
4Chemistry Department, Faculty of Science, Aswan University, Aswan, 81528, Egypt
Abstract
Root rot caused by Pythium aphanidermatum is one of diseases of olive trees. Three synthetic chemical compounds were tested to assess their inhibitory effect on Pythium aphanidermatum Ethyl 5-amino-7-((3,5-dimethyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate (7), Ethyl 5-amino-7-((3-hydroxy-5-methyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate(8) and Ethyl 5-amino-7-((5-amino-2,7-dihydroxypyrazolo[1,5-a]pyrimidin-3-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate(9) were synthesis to study their effect on mycelium growth, zoospore and oospore production of P. aphanidermatum isolated from young olive trees cultivated in Ain Seleen, Fayoum governorate, Egypt. Ethyl 5-amino-7-((3,5-dimethyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate (7), showed high efficiency as growth inhibition of fungal mycelia, followed by (pyrazolopyrimidine 9, and then pyrazolopyridine 8 at 10 mg/ L. Ethyl 5-amino-7-((3,5-dimethyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate (7), showed its ability to decline the production of zoo-spores and oospores of the fungus at concentration 300 mg/L, compared to other chemicals of Ethyl 5-amino-7-((5-amino-2,7-dihydroxypyrazolo[1,5-a]pyrimidin-3-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate(9), Ethyl 5-amino-7-((3-hydroxy-5-methyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate(8). Rate of inhibition in all treatments reached more than 85% in case of the use of Ethyl 5-amino-7-((3,5-dimethyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate (7). This study offers data for the use of Ethyl 5-amino-7-((3,5-dimethyl-1H-pyrazol-4-yl)diazenyl)-3,4,8,8a-tetrahydro-2H-pyrano[2,3-b]pyridine-6-carboxylate (7) in controlling fungal disease to olive feeder roots infected by P. aphanidermatum
Keywords
Mycelium growth; Oospores; Pyrazole; Pyrazolopyrimidine; Pythium aphanidermatum; Zoospores
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