Preparation, Characterization and Antimicrobial Activities of N'-((3-(hydroxyimino) butan-2-ylidene)-2 (phenylamino) acetohydrazide and Its Metal Complexes
Wahba, M., El-Saied, F., Al-Hakimi, A., Shakdofa, M. (2017). Preparation, Characterization and Antimicrobial Activities of N'-((3-(hydroxyimino) butan-2-ylidene)-2 (phenylamino) acetohydrazide and Its Metal Complexes. EKB Journal Management System, 60(1), 1-24. doi: 10.21608/ejchem.2017.620.1010
Mohammed Ahmed Wahba; Fathy A El-Saied; Ahmed N Al-Hakimi; Mohammed M Shakdofa. "Preparation, Characterization and Antimicrobial Activities of N'-((3-(hydroxyimino) butan-2-ylidene)-2 (phenylamino) acetohydrazide and Its Metal Complexes". EKB Journal Management System, 60, 1, 2017, 1-24. doi: 10.21608/ejchem.2017.620.1010
Wahba, M., El-Saied, F., Al-Hakimi, A., Shakdofa, M. (2017). 'Preparation, Characterization and Antimicrobial Activities of N'-((3-(hydroxyimino) butan-2-ylidene)-2 (phenylamino) acetohydrazide and Its Metal Complexes', EKB Journal Management System, 60(1), pp. 1-24. doi: 10.21608/ejchem.2017.620.1010
Wahba, M., El-Saied, F., Al-Hakimi, A., Shakdofa, M. Preparation, Characterization and Antimicrobial Activities of N'-((3-(hydroxyimino) butan-2-ylidene)-2 (phenylamino) acetohydrazide and Its Metal Complexes. EKB Journal Management System, 2017; 60(1): 1-24. doi: 10.21608/ejchem.2017.620.1010

Preparation, Characterization and Antimicrobial Activities of N'-((3-(hydroxyimino) butan-2-ylidene)-2 (phenylamino) acetohydrazide and Its Metal Complexes

Egyptian Journal of Chemistry
Article 1, Volume 60, Issue 1, February 2017, Page 1-24  XML PDF (2.2 MB)
DOI: 10.21608/ejchem.2017.620.1010
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Authors
Mohammed Ahmed Wahba1; Fathy A El-Saied2; Ahmed N Al-Hakimi3; Mohammed M Shakdofa email orcid 4
1Department of Inorganic Chemistry, National Research Centre, El-Bohouth St., Dokki, Cairo, Egypt.
2Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt
3Faculty of Science, Chemistry Department, Qassim University, Qassim, (KSA)
4Department of Inorganic Chemistry, National Research Centre, El-Bohouth St., Dokki, Cairo, Egypt
Abstract
A series of fourteen metal complexes synthesized by reaction a new acetohydrazide oxime ligand with metal ions (CuII, NiII, CoII, MnII, FeIII, ZnII, RuIII, UO2VI and VO2VI). The Ligand, N''-((3-(hydroxyimino)butan-2-ylidene)-2-(phenylamino)acetohydrazide was prepared by refluxing equimolar amount of phenyl amino acetohydrazide with 2,3-butanedione monoxime. The synthesized compounds were characterized using elemental and thermal analyses, NMR, IR, U.V spectroscopy, magnetic and conductance measurements. The results demonstrated that complexes (2), (3), (5-7) and (10-12) were formed in 1L:1M molar ratio, while complexes (4), (8), (9), (13) and (14) were found to afford M2L formulae. The ligand acted either as a neutral bidentate, neutral, monobasic or dibasic tridentate and dibasic tetradentate ligand chelated to the metal ions via nitrogen atoms of aceto-amino and azomethine groups, carbonyl oxygen atom in its enolic or ketonic form and/or protonated or deprotonated oximino nitrogen atom, adopting aoctahedral, tetrahedral or square planar geometry around metal ions. The antimicrobial activity of the ligand as well as the metal complexes was examined using Amphotericin B and Amoxicillin as drug-standards against Aspergillum niger (A.niger) and Escherichia coli (E. coli) respectively. The ligand demonstrates a high cytotoxicity against A. niger whereas it recorded a moderate activity against E. coli. It is interestingly found that zinc(II) complex (6), copper(II) complexes (8, 10) recorded higher activities than the Amphotericin B drug with 122%, 116% and 111.1% percentages respectively against A. niger zinc(II) complex (6) was also the most sensitive complex against E. coli with (94.1 %) comparable to Amoxicillin.
Keywords
acetohydrazide; Oxime; Metal complexes; 2; 3-Butanedione monoxime; Antimicrobial
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