Methotrexate Based Regimen versus Post-Transplant Cyclophosphamide in Allogeneic Hematopoietic Stem Cell Transplantation (Clinical Outcome), Egyptian Experience
Ibrahim, R., Soryal, G., Mohamed, H. (2021). Methotrexate Based Regimen versus Post-Transplant Cyclophosphamide in Allogeneic Hematopoietic Stem Cell Transplantation (Clinical Outcome), Egyptian Experience. EKB Journal Management System, 82(4), 727-732. doi: 10.21608/ejhm.2021.152995
Rasha I. Ibrahim; George B. Soryal; Haydi S. Mohamed. "Methotrexate Based Regimen versus Post-Transplant Cyclophosphamide in Allogeneic Hematopoietic Stem Cell Transplantation (Clinical Outcome), Egyptian Experience". EKB Journal Management System, 82, 4, 2021, 727-732. doi: 10.21608/ejhm.2021.152995
Ibrahim, R., Soryal, G., Mohamed, H. (2021). 'Methotrexate Based Regimen versus Post-Transplant Cyclophosphamide in Allogeneic Hematopoietic Stem Cell Transplantation (Clinical Outcome), Egyptian Experience', EKB Journal Management System, 82(4), pp. 727-732. doi: 10.21608/ejhm.2021.152995
Ibrahim, R., Soryal, G., Mohamed, H. Methotrexate Based Regimen versus Post-Transplant Cyclophosphamide in Allogeneic Hematopoietic Stem Cell Transplantation (Clinical Outcome), Egyptian Experience. EKB Journal Management System, 2021; 82(4): 727-732. doi: 10.21608/ejhm.2021.152995

Methotrexate Based Regimen versus Post-Transplant Cyclophosphamide in Allogeneic Hematopoietic Stem Cell Transplantation (Clinical Outcome), Egyptian Experience

The Egyptian Journal of Hospital Medicine
Article 22, Volume 82, Issue 4, January 2021, Page 727-732  XML PDF (487.3 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.152995
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Authors
Rasha I. Ibrahim1; George B. Soryal2; Haydi S. Mohamed email orcid 1
1Department of Internal Medicine and Clinical Hematology, Ain Shams University, Cairo, Egypt
2Department of Clinical Hematology, El Maadi Medical Compound, Cairo, Egypt.
Abstract
Background: Graft-versus-host disease (GVHD) is the major complication after allogeneic hematopoietic stem cell (HSCT) transplantation. GVHD prophylaxis is based on the use of calcineurin inhibitors. With the use of haploidentical HSCT, the use of cyclophosphamide increased after implantation (PT-Cy).
Objectives: Compare the clinical outcome of allogeneic HSCT after PT-Cy versus methotrexate (MTX) based regimens
Patients and methods: we included 137 patients from Bone Marrow Transplantation Units who received allogeneic HSCT. They were divided into 2 groups according to GVHD prophylaxis protocol: (group 1) included 102 patientsreceived (MTX) and cyclosporine (CSA) and(group 2) included 35 patients who received PT-Cy in combination with (CSA) and mycophenolate-mofetil (MMF).
Results: Neutrophil engraftment in group 1 at day 12.91 ± 5.67 vs at day14.69 ± 2.57 in group 2. The mean day of platelet recovery was 14.67 ± 1.89 and 14.69 ± 5.48 in group 1 and 2 respectively. Incidence of acute (a) GVHD at day 100 was 31.4% in group 1 vs 28.6% in group 2. The use of PT-CY reduced the risk of extensive chronic (c) GVHD to 17.1% (group 2) with high statistical significance (p Value <0.001). Overall survival (OS) at 5 years was 40.2%, 53.6% in group1 and 2 respectively (p value = 0.76), while disease free survival (DFS) was (81.3% vs 71.2%, p value 0.32).
Conclusion: The use of PT-Cy reduces the risk of extensive cGVHD.
 
Keywords
GVHD; HSCT; PT-CY
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