Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats
Abd El Ghany, M., Ramadan, A., Nagib, R., EL-Azaly, F. (2021). Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats. EKB Journal Management System, 12(2), 43-48. doi: 10.21608/jfds.2021.62433.1016
M. A. Abd El Ghany; Afaf-Haniem M. Ramadan; Rasha M. Nagib; Fayza M. EL-Azaly. "Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats". EKB Journal Management System, 12, 2, 2021, 43-48. doi: 10.21608/jfds.2021.62433.1016
Abd El Ghany, M., Ramadan, A., Nagib, R., EL-Azaly, F. (2021). 'Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats', EKB Journal Management System, 12(2), pp. 43-48. doi: 10.21608/jfds.2021.62433.1016
Abd El Ghany, M., Ramadan, A., Nagib, R., EL-Azaly, F. Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats. EKB Journal Management System, 2021; 12(2): 43-48. doi: 10.21608/jfds.2021.62433.1016

Comparative Study Between Virgin Coconut Oil and Omeprazole Drug on Ulcerative Colitis in Experimental Rats

Journal of Food and Dairy Sciences
Article 4, Volume 12, Issue 2, February 2021, Page 43-48  XML PDF (825.75 K)
Document Type: Original Article
DOI: 10.21608/jfds.2021.62433.1016
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Authors
M. A. Abd El Ghany email 1; Afaf-Haniem M. Ramadan2; Rasha M. Nagib2; Fayza M. EL-Azaly2
1Department of Home Economics, Faculty of Specific Education, Mansoura University, Egypt
2Department of Home Economics, Faculty of Specific Education,Mansoura University, Egypt
Abstract
This study aims to identify the curative effect of virgin coconut oil on ulcerative colitis(UC),the present study was carried (24) adult albino male rats Sprague –Dawley strain weighting 180 ±10g were classified into four groups,(6 rats each) the first group rats were fed on basal diet only control negative(-ve) group and three rat groups were injured of ulcerative colitisby intra colonic administration of acetic acid 4% given rectally by single dose ( 1 ml/ rat ) and reclassified into  control positive (+ve) group (fed on basal diet only), group treated with (20 mg/kg b.w) of  omeprazole drug and group treated with (2 ml per/ rat) daily of virgin coconut oil . The results revealed that, the control (+ve) group showed a significant decrease in final weight(FW) ,weight gain(WG) feed efficiency ratio (FER), organs weight of heart, kidney, and liver , catalase (CAT), superoxide dismutase (SOD), glutathione reduced (GSH), Glutathione reductase (GSR),Glutathione peroxidase (GPx(, glutathione-S-transferees (GST) and significant increase in malondialdehyde (MDA) , hydrogen peroxide (H2O2), C-reactive protein (CRP), interleukin-6 (IL-K) and prostaglandin (PG2) compared with control (- ve) group. The virgin coconut oil group showed a significant increase in (FW),(WG),(FI),(FER),organ stomach,(CAT),(SOD),(GSH),(GSR (GPx), (GST) but significant decrease in (MDA),(H2O2),(CRP),(ILK), (PG2)  compared with control (+ve) group . the study clearly showed that consumption virgin coconut oil has a role in treating rats with acetic acid-induced ulcerative colitis. It can be recommended that virgin coconut oil should be consumed daily to reduce the incidence of ulcerative colitis.
Keywords
virgin coconut oil; acetic acid; ulcerative colitis; experimental rat
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