Pharmacokinetic studies on Sulfamonomethoxine in rabbits | ||||
| Mansoura Veterinary Medical Journal | ||||
| Article 2, Volume 20, Issue 2, June 2019, Page 58-63 PDF (956.5 K) | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mvmj.2019.22.110 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Magdy Amer1; Mohamed Elsayed1; S Kazawaki2; W Fathy3; Eman El-Ashry 1
| ||||
| 1Pharmacology Department, Faculty of Veterinary Medicine, Mansoura University | ||||
| 2Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. | ||||
| 3Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University | ||||
| Abstract | ||||
| The present study was performed to determine the pharmacokinetics of sulfamonomethoxine (20mg/kg) in 5 rabbits after its oral and intravenous administration. Blood samples were collected immediately before (time 0) and at 0.08, 0.25, 0.5, 1, 3, 5 and 8 hours post-dosing to evaluate the pharmacokinetics of sulfamonomethoxine. Plasma sulfamonomethoxine concentrations were quantified with HPLC-UV, and plasma drug concentration versus time data after IV was best fitted to the two-compartment model, CHARacterized with the distribution phase (α) equaled to 2.05 h-1 with a distribution half-life [t0.5(α)] equaled to 0.61 h. The volume of distribution of (V1c) was 0.15 ml/kg., whereas the volume of distribution at a steady – state [Vdss] was 0.20 ml/kg, and the body clearance was 0.03 ml/ kg / h. After oral administration of SMM, plasma drug concentrations were best fitted to a two-compartment model, of which the mean half-life of absorption (t1/2ab) and elimination (t1/2β) were 0.02 and 1.99 h, respectively. The maximal absorption concentration (Cmax) was estimated as 114.06 µg/ml at 0.12 h, and the Area under the curve (AUC) was 340.42 µg/ml/h. | ||||
| Keywords | ||||
| rabbits; sulfamonomethoxine | ||||
|
Statistics Article View: 163 PDF Download: 435 |
||||
