Harmaline ameliorating role against liver cirrhosis via hepatic arginase-I activity modulation
Beltagy, D., Abdelsalam, K., Ali, T., elkey, M. (2021). Harmaline ameliorating role against liver cirrhosis via hepatic arginase-I activity modulation. EKB Journal Management System, (), -. doi: 10.21608/blj.2021.54605.1011
Doha Beltagy; Khloud Gamal Abdelsalam; Tarek Ali; mai elkey. "Harmaline ameliorating role against liver cirrhosis via hepatic arginase-I activity modulation". EKB Journal Management System, , , 2021, -. doi: 10.21608/blj.2021.54605.1011
Beltagy, D., Abdelsalam, K., Ali, T., elkey, M. (2021). 'Harmaline ameliorating role against liver cirrhosis via hepatic arginase-I activity modulation', EKB Journal Management System, (), pp. -. doi: 10.21608/blj.2021.54605.1011
Beltagy, D., Abdelsalam, K., Ali, T., elkey, M. Harmaline ameliorating role against liver cirrhosis via hepatic arginase-I activity modulation. EKB Journal Management System, 2021; (): -. doi: 10.21608/blj.2021.54605.1011

Harmaline ameliorating role against liver cirrhosis via hepatic arginase-I activity modulation

Biochemistry Letters
Articles in Press, Accepted Manuscript, Available Online from 06 March 2021  XML
Document Type: Original Article
DOI: 10.21608/blj.2021.54605.1011
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Authors
Doha Beltagy1; Khloud Gamal Abdelsalam email orcid 2; Tarek Ali3; mai elkey4
1Assistant professor of biochemistry, Faculty of Science, Damanhour University
2Biochemistry Division, Chemistry Department, Faculty of Science, Damanhour University, Egypt.
3Prof. of Biochemistry, Faculty of Science. Tanta University
4biochemistry, faculty of science , tanta university
Abstract
Liver cirrhosis, the 11th most common cause of death, is a severe disease that includes inflammation, oxidative damage, also immune response. Harmaline shows the antioxidant and anti-inflammatory mechanisms that aid in partial protection of hepatic cirrhosis.

Objective: This work aimed to evaluate the protection effect of harmaline against liver cirrhosis induced by thioacetamide in mice via arginase-1 enzyme activity modulation.

Methods: The study was carried out on forty male mice divided into four groups. Control group (GI), thioacetamide group (GII), harmaline group (GIII), and co-treated group (GIV). By the end of the experiment, arginase-1 activity and liver enzymes were measured in serum and liver tissue.
Results: The results showed that combined harmaline administration can cause significant suppression of liver inflammation by increasing ariginase-1 activity to nearly normal values. Inhibition of hepatic stellate cell activation and extracellular matrix deposition were also noticed.

Conclusion: Harmaline has protective role against liver cirrhosis induced by thioacetamide in mice. It can be therapeutically used as a safe liver support after further in vivo studies.
Keywords
Thioacetamide, Cirrhosis; Harmaline; Arginase; liver
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