Effect of Platelet-Rich Plasma Intra Articular Injection on Patients with Primary Knee Osteoarthritis
Elkadery, N., Elwy, M., Ghaniema, E., Hammad, A., Sakr, H. (2015). Effect of Platelet-Rich Plasma Intra Articular Injection on Patients with Primary Knee Osteoarthritis. EKB Journal Management System, 59(1), 227-232. doi: 10.12816/0012180
Nadia Abdel Salam Elkadery; Mohammed Aly Elwy; Eman Mahmoud Ghaniema; Ahmed Ibrahim Hammad; Hossam Moussa Sakr. "Effect of Platelet-Rich Plasma Intra Articular Injection on Patients with Primary Knee Osteoarthritis". EKB Journal Management System, 59, 1, 2015, 227-232. doi: 10.12816/0012180
Elkadery, N., Elwy, M., Ghaniema, E., Hammad, A., Sakr, H. (2015). 'Effect of Platelet-Rich Plasma Intra Articular Injection on Patients with Primary Knee Osteoarthritis', EKB Journal Management System, 59(1), pp. 227-232. doi: 10.12816/0012180
Elkadery, N., Elwy, M., Ghaniema, E., Hammad, A., Sakr, H. Effect of Platelet-Rich Plasma Intra Articular Injection on Patients with Primary Knee Osteoarthritis. EKB Journal Management System, 2015; 59(1): 227-232. doi: 10.12816/0012180

Effect of Platelet-Rich Plasma Intra Articular Injection on Patients with Primary Knee Osteoarthritis

The Egyptian Journal of Hospital Medicine
Article 8, Volume 59, Issue 1, April 2015, Page 227-232  XML PDF (443.46 K)
Document Type: Original Article
DOI: 10.12816/0012180
View on SCiNiTO View on SCiNiTO
Authors
Nadia Abdel Salam Elkadery1; Mohammed Aly Elwy1; Eman Mahmoud Ghaniema1; Ahmed Ibrahim Hammad1; Hossam Moussa Sakr2
1Departments of Physical medicine, Rheumatology & Rehabilitation Faculty of medicine, Ain Shams University
2Departments of Physical medicine Radiodiagnosis Faculty of medicine, Ain Shams University
Abstract
   Background: Osteoarthritis (OA) is the most common type of arthritis. It is a degenerative joint disease. OA is usually defined according to radiographic changes. Conventional radiographs (CR) were considered the most relevant outcome measure to assess the progression of OA in clinical trials and epidemiological studies. Many modalities are used in treatment of knee OA. There is a distinct need for new procedures that are cost effective by reducing the need for pharmaceutical and surgical management, while targeting the biochemical process of OA. Platelet-rich plasma (PRP) is one of these new procedures. PRP was found to increase hyaluronic acid (HA) concentration, stabilizing angiogenesis in patients with osteoarthritic knees.
   Aim of the study: Was to assess the value of intra articular injection of autologous platelet rich plasma in management of knee osteoarthritis.
   Patients and methods: This study was conducted on 40 patients with primary knee osteoarthritis, divided into 2 groups; study group treated with 3 injections of PRP, and control group treated with single dosed high-molecular weight HA. Clinical assessment and visual analogue scale (VAS) scoring were done pretreatment and 3 months post treatment.
   Results: Clinical improvement and reduction of VAS in both groups which is significant at the study group. Conclusion: PRP injection could be considered as a simple, safe, effective and non-palliative treatment that may promote cartilage healing in knee osteoarthritis as it improve the clinical condition and the function of the joint. Hence, it may represent a useful addition to the available therapeutic options for knee osteoarthritis.
 
Keywords
knee; osteoarthritis; platelet-rich plasma
Statistics
Article View: 125
PDF Download: 271