Bioactivity Study of Streptomycin Sulfate loaded Chitosan/Bioglass Scaffold.
Al-esnawy, A., Abd raboh, A., Bakr, A., Tohamy, K. (2021). Bioactivity Study of Streptomycin Sulfate loaded Chitosan/Bioglass Scaffold.. EKB Journal Management System, 22(1), 1-11. doi: 10.21608/ejbbe.2021.66203.1041
Abdelrahman Al-esnawy; Ahmed Abd raboh; Ahmed Bakr; Khairy Tohamy. "Bioactivity Study of Streptomycin Sulfate loaded Chitosan/Bioglass Scaffold.". EKB Journal Management System, 22, 1, 2021, 1-11. doi: 10.21608/ejbbe.2021.66203.1041
Al-esnawy, A., Abd raboh, A., Bakr, A., Tohamy, K. (2021). 'Bioactivity Study of Streptomycin Sulfate loaded Chitosan/Bioglass Scaffold.', EKB Journal Management System, 22(1), pp. 1-11. doi: 10.21608/ejbbe.2021.66203.1041
Al-esnawy, A., Abd raboh, A., Bakr, A., Tohamy, K. Bioactivity Study of Streptomycin Sulfate loaded Chitosan/Bioglass Scaffold.. EKB Journal Management System, 2021; 22(1): 1-11. doi: 10.21608/ejbbe.2021.66203.1041

Bioactivity Study of Streptomycin Sulfate loaded Chitosan/Bioglass Scaffold.

Egyptian Journal of Biomedical Engineering and Biophysics
Article 1, Volume 22, Issue 1, 2021, Page 1-11  XML PDF (1.96 MB)
Document Type: Original Article
DOI: 10.21608/ejbbe.2021.66203.1041
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Authors
Abdelrahman Al-esnawy email orcid 1; Ahmed Abd raboh2; Ahmed Bakr3; Khairy Tohamy4
1Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
2Biophysics Branch, Physics Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
3Spectroscopy Department, Physics Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.
4Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt
Abstract
A novel type of drug-delivery scaffold based on bioactive glass (BG) and of Chitosan (CH) loaded with Streptomycin Sulfate (STRS) were prepared by improved freeze-drying. we synthesized a BG using the sol-gel method, mixed with a constant ratio of CH (BG:CH = 1:1 wt %). So, we have two samples: CH/BG (0% STRS) and STRS-loaded CH/BG (20% STRS) scaffold. The development of new composite scaffolds based on the combination of (CH) with (BG) scaffolds as a carrier to an antibiotic drug (STRS) for the application in bone tissue engineering. In this work, CH/BG and STRS-loaded CH/BG scaffolds. The obtained materials were characterized by different techniques X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Field Emission Gun Scanning Electron Microscopy (FEG-SEM), and Energy Dispersive X-ray Analysis (EDXA) before and after soaking in (SBF). Bioactivity results of the prepared scaffolds showed exhibits a deposition of a layer of Calcium Phosphate on their surfaces. The results showed that the scaffolds had high porosity with open pores. Furthermore, the BG particles were homogenously distributed within the scaffolds. According to the obtained results, STRS-loaded CH/BG (20% STRS) sample has higher bioactivity than CH/BG (0% STRS) sample.
Keywords
Bioglass/Chitosan; Scaffold; Streptomycin Sulfate; Bioactivity; antibacterial
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