The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine
El-zieny, A., Soliman, A., ElDek, S., Farghali, A. (2018). The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine. EKB Journal Management System, 64(1), 51-63. doi: 10.21608/vmjg.2018.156217
Amany El-zieny; A Soliman; S ElDek; A Farghali. "The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine". EKB Journal Management System, 64, 1, 2018, 51-63. doi: 10.21608/vmjg.2018.156217
El-zieny, A., Soliman, A., ElDek, S., Farghali, A. (2018). 'The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine', EKB Journal Management System, 64(1), pp. 51-63. doi: 10.21608/vmjg.2018.156217
El-zieny, A., Soliman, A., ElDek, S., Farghali, A. The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine. EKB Journal Management System, 2018; 64(1): 51-63. doi: 10.21608/vmjg.2018.156217

The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine

Veterinary Medical Journal (Giza)
Article 5, Volume 64, Issue 1, 2018, Page 51-63  XML PDF (385.7 K)
Document Type: Original Article
DOI: 10.21608/vmjg.2018.156217
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Authors
Amany El-zieny* 1; A Soliman1; S ElDek2; A Farghali2
1Department of Rabies , Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt
2Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt
Abstract
The use of engineered nanomaterials (ENMs) that possess unique physicochemical properties in adjuvants enable researchers to achieve improved protection against infectious diseases. Recently, several studies were conducted on the use of nanoparticles as adjuvant to enhance the   immunogenicity of antigen and decrease the dose of immunologic adjuvants. In this work, we synthesized aluminum hydroxide nanoparticles using sonochemical technique nanoparticles, were characterized using X-ray diffraction, high resolution transmission electron microscope and zeta size potential. The result demonstrated that the size of aluminum hydroxide nanoparticles was 51 nm in diameter  that exhibited more potent antigen-specific antibody response than that of the micro-sized aluminum hydroxide gel particles (9 mm), so the prepared nano aluminum hydroxide was used as adjuvant for the inactivated rabies vaccine comparing with the traditional aluminum hydroxide gel and  the dose of  the prepared inactivated nana rabies vaccine was reduced, inducing high prolonged potent immune response in vaccinated dog.
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