Biological Evaluation for Specific Fungal Aflatoxin Contamination in Some Beans of Rat's Diet | ||||
| Journal of High Institute of Public Health | ||||
| Article 4, Volume 36, Issue 3, July 2006, Page 691-700 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2006.156341 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Neven M M. Mahmoud* | ||||
| Department of Special & Nutr, Food Technology Research Institute, Agriculture Research Center, Cairo, Egypt | ||||
| Abstract | ||||
| The toxigenic metabolic impact associated fungi contamination with some beans in rat consumption was investigated. Sever blood changes have been noticed in association of final body weight and organ deviation. It was seen that aflatoxin strongly decreases the blood albumin, meanwhile, significantly raised up the globulin. Liver function has also been elevated more times, especially with the contamination of Aspergillus paristicus. This strain has dramatically abuse liver tissues. In comparing to the control, the histopathological examination of liver and brain were severely adversely affected. It cause a lot of pathological disorders such as dilatation and congestion of hepatoprtal vessels, Kupffer cells activation, hepatocytes necrosis, hepatocytes active unclei, epithelial vascular lining of bile duct, portal infiltration, lucocytic cells, and hepatocytes cytomegaly nuclei. It is worth to mention that the ranking number used for liver function were identically compromising that of its tissue histopathological findings. It is concluded that although aflatoxins are potent hepatotoxic and carcinogenic metabolites produced by the fungi Aspergillus flavus, A. parasiticus or others, food contamination with fungus, especially A paristicus, is a real dangerous task to the liver and adversely affects its subclinical expectancy. Hence, these vegetables might contain natural factors that enhance aflatoxin B1 carcinogenicity. In brief, the biological evaluation appeared in blood changes, enzymes and tissues in connection to suffering of permanent liver damage after being exposed to this batch of contaminated bean show the degree of the adverse health aspect of these toxins. | ||||
| Keywords | ||||
| Biological Evaluation; specific Fungal Aflatoxin; Beans of Rat’s Diet | ||||
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