Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 20, Volume 57, Issue 1, October 2014, Page 598-611 PDF (2.24 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.12816/0008491 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Maiada Moustafa1; Ahmed Said Alazzounui2; Mohamed Said Gabri2 | ||||
| 1Department of Zoology and Entomology, Faculty of Science, Helwan University | ||||
| 2Department of Zoology and Entomology, Faculty of Science, Helwan University. | ||||
| Abstract | ||||
| Background: Different studies have demonstrated that aging clearly affects male fertility which may be attributed to the androgen deficiency. Reactive oxygen species play a central role in the pathophysiology in the aged-related decrease in male fertility. Some antioxidants have ameliorative effects on different aged organs. Material and Methods: The present study aimed to evaluate the effects of some antioxidants on aged testes. Ten adult and fifty aged male albino rats (Rattus albus) were divided into six groups. Group I (control adult), Group II (control aged), Group III (Vitamin E-treated aged), Group IV (Vitamin C-treated aged), Group V (Zinc sulphate-treated aged), Group VI (Vitamin E-, Vitamin C- and Zinc Sulphate-treated aged). Vitamin E, Vitamin C and Zinc were administrated in doses 2.52 mg, 3.15 mg and 0.693 mg, respectively. Histological and ultrastructural evaluation of the testes were examined as well as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), total and free testosterone levels in the serum were measured. Counting the number of litters per animal and the teratogenic effects was noticed. Results: Giving zinc alone or combined with other antioxidants gave better ameliorative effects on the testicular structure and hormonal levels in the serum. No teratogenic effects of the aged animals`offspring were noticed. | ||||
| Keywords | ||||
| aging; testis; zinc; Vitamin E; vitamin c; combined antioxidants | ||||
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