Factorial Design Optimization of Microwave Digestion for Macro and Microelements in Pregnant Women and Diabetics Multivitamin/Multielement Preparations by Inductive Coupled Plasma Mass Spectrometry (ICPMS) | ||||
| Egyptian Journal of Chemistry | ||||
| Article 4, Volume 64, Issue 7, July 2021, Page 3245-3254 PDF (449.79 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.49815.3027 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
ABUZAR ALBADRI   1; Mohamed Elmukhtar AbdelAziz2; Hassan Ahmmad3
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| 17587 king Saud 9 | ||||
| 2Department of Chemistry, Sudan University of Science & Technology, Khartoum, Sudan | ||||
| 3Department of Chemistry, Faculty of Science, University of Khartoum, Khartoum, Sudan | ||||
| Abstract | ||||
| In the present work, the microwave digestion procedure for the determination of Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Se, V and Zn in multivitamin/multielement (MVM) preparations used for pregnant women and diabetics employing ICP-MS, was optimized by factorial design 33 (27 runs). The microwave digestion conditions temperature (160, 180 and 200ºC), acid mixture volume (3.9, 5.2 and 6.5 ml) and radiation period (10, 15 and 20 min) were selected as factors. Moreover, a multiple response (MR) was built to establish a compromise conditions between the elements. The optimum conditions were found to be 160ºC, 6.5 ml, 20 min for temperature, acid mixture volume and radiation period, respectively. The procedure was validated using standard reference material (SRM3280) and elements recoveries were found to be in the range 88 - 107% and was applied to determination of Ca, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Se, V and Zn in commercial MVM samples obtained from the local market. | ||||
| Keywords | ||||
| Microwave digestion; MVM; Factorial design; ICP-MS | ||||
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