Assessment of follicular fluid paraoxonase activity with pregnancy outcomes in women undergoing IVF/ICSI
Ahmed, M., Wadood, S., Mahdi, Q. (2021). Assessment of follicular fluid paraoxonase activity with pregnancy outcomes in women undergoing IVF/ICSI. EKB Journal Management System, 64(6), 2895-2902. doi: 10.21608/ejchem.2021.55291.3162
M. A. Ahmed; Sh. A. Wadood; Q. A. Mahdi. "Assessment of follicular fluid paraoxonase activity with pregnancy outcomes in women undergoing IVF/ICSI". EKB Journal Management System, 64, 6, 2021, 2895-2902. doi: 10.21608/ejchem.2021.55291.3162
Ahmed, M., Wadood, S., Mahdi, Q. (2021). 'Assessment of follicular fluid paraoxonase activity with pregnancy outcomes in women undergoing IVF/ICSI', EKB Journal Management System, 64(6), pp. 2895-2902. doi: 10.21608/ejchem.2021.55291.3162
Ahmed, M., Wadood, S., Mahdi, Q. Assessment of follicular fluid paraoxonase activity with pregnancy outcomes in women undergoing IVF/ICSI. EKB Journal Management System, 2021; 64(6): 2895-2902. doi: 10.21608/ejchem.2021.55291.3162

Assessment of follicular fluid paraoxonase activity with pregnancy outcomes in women undergoing IVF/ICSI

Egyptian Journal of Chemistry
Article 18, Volume 64, Issue 6, June 2021, Page 2895-2902  XML PDF (450.46 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.55291.3162
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Authors
M. A. Ahmed1; Sh. A. Wadood1; Q. A. Mahdi2
1Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.
2Kamal Al-Samarai IVF Hospital, Ministry of Health, Baghdad, Iraq
Abstract
The search for a reliable marker to predict pregnancy success is not yet identified. This study aims to evaluate paraoxonase activities (PON1) in follicular fluid (FF) and their correlation with oocyte yield, fertilization, and clinical pregnancy (CP). Methods: The study included 99 women aged 22- 37 years old who were undergoing IVF/ICSI, were divided into fertile, which represents the control group consisting of 25 participants, and the infertile group, which was subdivided into 21 patients with PCOS, 26 patients with a low level of AMH, as well as 27 patients with unknown cause of infertility. The FF Basal PON1, salt stimulated PON1, and arylesterase activities were measured using the spectrophotometry method. Results: The PON1 basal activity of the PCOS group was higher (P<0.05) when compared with the control and UI groups. The PON1 arylesterase activity of the PCOS group was higher (P<0.05) when compared with control, UI, and low AMH groups. Each group showed a difference (P<0.05)in the pregnancy success in PCOS, low AMH, and UI groups but not in the control group. Conclusion: An increase in FF antioxidants seems to be a negative fertilization indicator, which may represent an adverse ovarian condition that triggered anti-oxidant behavior.
Keywords
Paraoxonase1 activity (PON1), clinical pregnancy (CP), follicular fluid (FF); infertility, in vitro fertilization (IVF)
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