Solvent-free synthesis of new chalcone derivatives from 3-nitro phthalic acid and evaluation of their biological activities | ||||
| Egyptian Journal of Chemistry | ||||
| Article 25, Volume 64, Issue 6, June 2021, Page 2963-2968 PDF (831.98 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.55742.3176 | ||||
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| Authors | ||||
| Luma S. Ahamed1; Rana Abid Ali1; Rana S. Ahmed2 | ||||
| 1Department of Chemistry, College of Science, University of Baghdad Jadiriya, Baghdad, Iraq | ||||
| 2Department of Pharmacy Al-Esraa University College, Baghdad, Iraq | ||||
| Abstract | ||||
| Synthesis of 2-(4-Acetyl-phenyl)-4-nitro-isoindole-1, 3-dione chalcones were performed by fusion of 3-nitro phthalic anhydride with p-aminoacetophenone. Then the later was grinded with different aromatic aldehydes in the presence of sodium hydroxide to produce new chalcones derivatives A3-10 without using any solvent formation of new N-arylphthailimide chalcones were confirmed by FTIR,1HNMR, 13CNMR spectroscopy and all final compounds were tested for their antifungal and antibacterial activity some of them showed more biological activity than the standard drugs.. | ||||
| Keywords | ||||
| Chalcone; 3-nitro phthalic anhydride; biological activity | ||||
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