Synthesis and Characterization of New Derivatives Of Metformin with Expected Anti-diabetic Effects | ||||
| Egyptian Journal of Chemistry | ||||
| Article 27, Volume 64, Issue 6, June 2021, Page 2973-2982 PDF (1.1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.55914.3194 | ||||
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| Authors | ||||
| Ahmed Solaiman Hamed; Ehab M. Ali; Asma Adil Gayed | ||||
| Department of Chemistry, College of Applied Science, University of Fallujah, Fallujah, Iraq | ||||
| Abstract | ||||
| Metformin considered as a drug that widely used in the treatment of diabetes type-2 patients, and it is recommended for management of hyperglycaemia as the first-line agent. This research included the preparation of new derivatives of metformin 1-8 which contain in their composition both cyclic imide and metformin components with expected anti-diabetic effects, via two methods, the first involved reacting metformin with different anhydrides (maleic, succinic, citraconic, phthalic, pyridinic, , pyromillitic) in the presence of glacial acetic acid as a solvent and dehydrating agent. The second involved smelting of metformin with equimolar amount of anhydrides (1,8-naphthalicanhydride and 1,4,6,8-naphthalicdianhydride).The compositions of the synthesized compounds 1-8 were confirmed using FT-IR spectroscopy, 1HNMR spectroscopy and elemental analysis (C, H, N, O), and the practical results were in agreement with the expected results. | ||||
| Keywords | ||||
| Cyclic imide; Metformin; Dimethylbiguanide; diabetic; anhydride | ||||
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