Tailoring Nano-Copolymer/CNTs Composite and its Application in Drug Delivery | ||||
| Egyptian Journal of Chemistry | ||||
| Article 13, Volume 64, Issue 7, July 2021, Page 3335-3349 PDF (1.19 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.60541.3303 | ||||
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| Authors | ||||
mohamed kamal darwish  1; mohamed Shaban Said2; Rokaya Aly Sobh 3; Ahmed Ahmed abdel-khalek1
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| 1Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt | ||||
| 2Physics Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. Physics Department, Faculty of Science, Islamic University of Madinah, P. O. Box: 170, AlMadinah Almonawara 42351, Saudi Arabia | ||||
| 3Polymer and Pigment Department, National Research Centre, Giza, Egypt | ||||
| Abstract | ||||
| This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these ground-breaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7. | ||||
| Keywords | ||||
| MWCNTs/polymer nanocomposite; 5- fluorouracil; microemulsion polymerization; methyl methacrylate; 2-hydroxyethyl methacrylate; drug delivery systems | ||||
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