Comparative Study on the Effect of C667T and A1298C Polymorphism in Preeclampsic Cases
EL Baz, R., Ramadan, M., EL Shershaby, E., Fayad, E., Shaltot, A. (2014). Comparative Study on the Effect of C667T and A1298C Polymorphism in Preeclampsic Cases. EKB Journal Management System, 56(1), 355-367. doi: 10.21608/ejhm.2014.15694
Rizk Ahmed EL Baz; Manal Mohamed Ramadan; Effat Mahmoud EL Shershaby; Eman Fayad; Ali Ali Shaltot. "Comparative Study on the Effect of C667T and A1298C Polymorphism in Preeclampsic Cases". EKB Journal Management System, 56, 1, 2014, 355-367. doi: 10.21608/ejhm.2014.15694
EL Baz, R., Ramadan, M., EL Shershaby, E., Fayad, E., Shaltot, A. (2014). 'Comparative Study on the Effect of C667T and A1298C Polymorphism in Preeclampsic Cases', EKB Journal Management System, 56(1), pp. 355-367. doi: 10.21608/ejhm.2014.15694
EL Baz, R., Ramadan, M., EL Shershaby, E., Fayad, E., Shaltot, A. Comparative Study on the Effect of C667T and A1298C Polymorphism in Preeclampsic Cases. EKB Journal Management System, 2014; 56(1): 355-367. doi: 10.21608/ejhm.2014.15694

Comparative Study on the Effect of C667T and A1298C Polymorphism in Preeclampsic Cases

The Egyptian Journal of Hospital Medicine
Article 10, Volume 56, Issue 1, July 2014, Page 355-367  XML PDF (541.67 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2014.15694
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Authors
Rizk Ahmed EL Baz1; Manal Mohamed Ramadan2; Effat Mahmoud EL Shershaby2; Eman Fayad1; Ali Ali Shaltot1
1Faculty of Medicine, Genetic department at Mansoura University
2Faculty of Science, Zoology department at Mansoura University
Abstract
Objective: To identify polymorphism of methylenetetrahydrofolate reductase gene in women suffering from preeclampsia.
                                  Study design:   From 142 pregnant women we identify 92 women suffer from preeclampsia and 50 healthy controls with normal pregnancy matched for age and socioeconomic status, preeclampsic patient classified as mild preeclampsia 42(45.7%) and severe preeclampsia 50(54.3%). Blood samples were tested for DNA polymorphism affecting thrombophilia methylenetetrahydrofolate reductase C677T and   A1298C.
Results: Homozygous TT genotype, T allele of C677T polymorphism has a significantly higher frequency among preeclampsic cases compared to healthy controls (OR=21.7, 1.46, respectively). Thus TT genotype and T allele may be considered as genetic risk factors for preeclampsic cases. on the other hand, non significant association in either genotype among preeclampsic cases compared to controls regarding to A1298C.
 
Keywords
C667T gene; A1298C; preeclampsia
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