Physiological consequence of sleep deprivation on healthy volunteers | ||||
| Journal of Environmental Sciences. Mansoura University | ||||
| Article 1, Volume 49, Issue 2, June 2020, Page 28-36 PDF (665.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/joese.2020.158386 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| N. M. El_Sawi; M. R. Edrees; G. M. | ||||
| Mansours University, Faculty of Science, Zoology Department | ||||
| Abstract | ||||
| In most biological processes in the human body, sufficient sleep time and length during the night is very critical while, the opposite is associated with adverse physical health issues. Forty volunteers 25-35 years old were chosen for participation in this study, 20 has normal sleep at night and 20 exposed to sleep < br />deprivation either voluntary or involuntary, for at least 2 months. Sleep deprived group showed decline in RBCs, Hb, Ht% incorporated with increase in total WBCs and most of their subpopulations especially lymphocytes and neutrophils, glucose concentration, glycated hemoglobin, ghrelin, ACTH, cortisol, melatonin levels, total lipids and triacylglycerol in association with significant decline in leptin and insulin levels. Regarding antioxidant parameters and oxidative stress markers, SOD activity and GSH level declined but, CAT activity, MDA and PC significantly exceeded. Regarding CD4 and CD8 %, they were significantly raised in sleep < br />deprived group. In conclusion, it seems that, sleep deprivation adversely affects metabolic processes, reduces antioxidant status and declines immune system, meanwhile, sleep aid for recuperation from most disease status, improve immune system and restore body activity | ||||
| Keywords | ||||
| sleep deprivation; oxidative stress; hormonese | ||||
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