Impact of Premature Progesterone Rise on Intracytoplasmic Sperm Injection Outcomes Using Gonadotropin-Releasing Hormone Antagonist Protocol
Helmy, M., Seksaka, M., Hafez, E., Elnagar, W. (2023). Impact of Premature Progesterone Rise on Intracytoplasmic Sperm Injection Outcomes Using Gonadotropin-Releasing Hormone Antagonist Protocol. EKB Journal Management System, 29(1), 193-200. doi: 10.21608/zumj.2021.61722.2123
Mohamed Ahmed Helmy; Mahmoud Attia Seksaka; Eman Mahfouz Hafez; Walid Mohamed Elnagar. "Impact of Premature Progesterone Rise on Intracytoplasmic Sperm Injection Outcomes Using Gonadotropin-Releasing Hormone Antagonist Protocol". EKB Journal Management System, 29, 1, 2023, 193-200. doi: 10.21608/zumj.2021.61722.2123
Helmy, M., Seksaka, M., Hafez, E., Elnagar, W. (2023). 'Impact of Premature Progesterone Rise on Intracytoplasmic Sperm Injection Outcomes Using Gonadotropin-Releasing Hormone Antagonist Protocol', EKB Journal Management System, 29(1), pp. 193-200. doi: 10.21608/zumj.2021.61722.2123
Helmy, M., Seksaka, M., Hafez, E., Elnagar, W. Impact of Premature Progesterone Rise on Intracytoplasmic Sperm Injection Outcomes Using Gonadotropin-Releasing Hormone Antagonist Protocol. EKB Journal Management System, 2023; 29(1): 193-200. doi: 10.21608/zumj.2021.61722.2123

Impact of Premature Progesterone Rise on Intracytoplasmic Sperm Injection Outcomes Using Gonadotropin-Releasing Hormone Antagonist Protocol

Zagazig University Medical Journal
Article 24, Volume 29, Issue 1, January 2023, Page 193-200  XML PDF (479.31 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.61722.2123
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Authors
Mohamed Ahmed Helmy email orcid 1; Mahmoud Attia Seksaka2; Eman Mahfouz Hafez3; Walid Mohamed Elnagar3
1Obstetrics & Gynaecology Department, Faculty of Medicine, Zagazig University, Egypt
2Professor of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt
3Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Premature progesterone rise (PPR) refers to an increase in serum progesterone (P4) levels on or before the human chorionic gonadotropin (hCG) trigger day. This work aimed to evaluate the impact of serum P4 levels on the day of hCG trigger on the outcomes of intracytoplasmic sperm injection (ICSI) cycles using the gonadotropin-releasing hormone (GnRH) antagonist protocol. Methods: The prospective cohort study was conducted at the Cytogenetics and Endoscopy unit, Obstetrics & Gynaecology Department, Zagazig University, including 150 women having ICSI/fresh-embryo transfer (ET). Each patient had one trial of ICSI/fresh ET cycle. In the study, patients were subjected to controlled ovarian stimulation (COS) using a GnRH antagonist protocol. P4 levels were measured on the hCG trigger day (hCG-P4), and the results were correlated to the outcomes of the ICSI cycle. Results: There was a statistically significant negative correlation between hCG-P4 and the top-quality embryo (TQE) rate. No significant association was found between hCG-P4 level and clinical pregnancy, ongoing pregnancy, or miscarriage. The cutoff for hCG-P4 predicting unsuccessful achievement of clinical pregnancy was ≥ 0.925 (p>0.05). Patients with hCG-P4 level ≥0.925 ng/ml had a significantly lower TQE rate than patients with hCG-P4
Keywords
Progesterone; Gonadotropin-releasing hormone antagonist; Intracytoplasmic sperm injection; Human chorionic gonadotropin
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