Significance of Serum Ischemia-Modified Albumin Level as a Marker of Neonatal Sepsis
Abdel-Aty, R., Morsy, S., Ahmed, H., Elgebaly, S. (2023). Significance of Serum Ischemia-Modified Albumin Level as a Marker of Neonatal Sepsis. EKB Journal Management System, 29(1), 17-22. doi: 10.21608/zumj.2021.58298.2093
Rana Abbas Abdel-Aty; Saeed Mohammed Morsy; Hanan Samir Ahmed; Sherif Mohammed Elgebaly. "Significance of Serum Ischemia-Modified Albumin Level as a Marker of Neonatal Sepsis". EKB Journal Management System, 29, 1, 2023, 17-22. doi: 10.21608/zumj.2021.58298.2093
Abdel-Aty, R., Morsy, S., Ahmed, H., Elgebaly, S. (2023). 'Significance of Serum Ischemia-Modified Albumin Level as a Marker of Neonatal Sepsis', EKB Journal Management System, 29(1), pp. 17-22. doi: 10.21608/zumj.2021.58298.2093
Abdel-Aty, R., Morsy, S., Ahmed, H., Elgebaly, S. Significance of Serum Ischemia-Modified Albumin Level as a Marker of Neonatal Sepsis. EKB Journal Management System, 2023; 29(1): 17-22. doi: 10.21608/zumj.2021.58298.2093

Significance of Serum Ischemia-Modified Albumin Level as a Marker of Neonatal Sepsis

Zagazig University Medical Journal
Article 3, Volume 29, Issue 1, January 2023, Page 17-22  XML PDF (387.31 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.58298.2093
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Authors
Rana Abbas Abdel-Aty email 1; Saeed Mohammed Morsy2; Hanan Samir Ahmed3; Sherif Mohammed Elgebaly2
1zagazige zagazige sharquia
2pediatrics department, faculty of medicine, zagazig university, sharquia
3clinical pathology department, faculty of medicine, zagazig uiversity, sharquia
Abstract
Background: Neonatal sepsis is a major cause of morbidity and mortality in the neonatal period. Clinical manifestations range from subclinical infection to severe manifestations of focal or systemic disease septic shock. A suitable, economic, sensitive and specific endogenous marker is crucially needed to detect sepsis at an early stage. Objectives: We aimed to identify whether ischemia modified albumin (IMA) level can be used as a marker in the diagnosis of neonatal sepsis and evaluate its prognostic significance. Patients and Methods: A case control study was conducted on 36 newborn babies (18 with neonatal sepsis and 18 without sepsis based on blood culture). Babies were subjected to full medical history, thorough clinical examination and routine laboratory investigations according to our local standards. Serum ischemia modified albumin was measured and correlated to clinical symptoms and prognosis. Results: There was a significant difference between sepsis group and control group as regards mean serum IMA level (103.7± 31.82 versus 85.36 ± 14.07 ng/ ml) with positive predictive value 80% and negative predictive value 65%. Conclusion: We concluded that IMA seems to be a useful biomarker for the diagnosis of neonatal sepsis.
Keywords
neonatal sepsis; ischemia modified albumin; neonates; marker
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