The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats
El Kholy, W., Serag, H., zakaria, A., El Metwaly, A. (2013). The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats. EKB Journal Management System, 53(1), 1036-1048. doi: 10.12816/0001666
Wafaa El Kholy; Hanaa Serag; Asharf zakaria; Aziza El Metwaly. "The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats". EKB Journal Management System, 53, 1, 2013, 1036-1048. doi: 10.12816/0001666
El Kholy, W., Serag, H., zakaria, A., El Metwaly, A. (2013). 'The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats', EKB Journal Management System, 53(1), pp. 1036-1048. doi: 10.12816/0001666
El Kholy, W., Serag, H., zakaria, A., El Metwaly, A. The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats. EKB Journal Management System, 2013; 53(1): 1036-1048. doi: 10.12816/0001666

The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats

The Egyptian Journal of Hospital Medicine
Article 31, Volume 53, Issue 1, October 2013, Page 1036-1048  XML PDF (281.47 K)
Document Type: Original Article
DOI: 10.12816/0001666
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Authors
Wafaa El Kholy; Hanaa Serag; Asharf zakaria; Aziza El Metwaly
Zoology department ,Faculty of Science,Mansoura University, Egypt
Abstract
Aim of the work:the present study was carried out to investigate the possible ameliorating effects of three herbs: hops(H) 1.5g/kg diet , rosemary(R) 5g/kg diet  and cat's claw (C C) 1.7g/kg diet on hepatic toxicity induced by 7,12-Dimethyl benz(A)antheracene , a hydrocarbon  involves various negative consequence for human health and ecosystems conversation .Results:in this work,48 female rats at 50 day of age were divided into 8 groups; control ,hops(H), rosemary(R), cat's claw(CC),DMBA, DMBA+H,DMBA+R and DMBA+CC groups.Results:the results indicated that a single intraperitonial  (i.p) dose of DMBA (30mg/Kg b.W) caused significant decrease in the percentage of body weight  gain, but an increase in the hepatosomatic  index. In addition , the results illustrated an increase in the liver malondialdehyde (MDA) contents and hydrogen peroxide levels (H2O2) accompanied by significant decrease in reduced glutathione (GSH) content and superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities.The results, also  reported significant decrease in serum total proteins,  total albumin ,  globulin  and liver total protein but serum total bilirubin was significantly elevated in the DMBA intoxicated group. Furthermore, aspartate aminotransaminase (ASAT), alanine aminotransaminase (ALAT) , γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities were significantly increased in serum but significantly decreased in the liver.
On the other hand, intake of  hops, rosemary and cat's claw minimize the disturbances observed in most of the tested parameter's resulted from DMBA administration and improve the liver functions mostly in the following order, rosemary ˃  hops ˃ cat's claw. Conclusion: it can be concluded that intake of such herbs (hops , rosemary, cat's claw)may be effective in reducing DMBA toxicity.
 
 
Keywords
natural products; Hepatotoxicity; Rats
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