3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities | ||||
| Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
| Article 3, Volume 4, Issue 2, April 2021, Page 81-86 PDF (638.5 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/jabps.2020.52641.1113 | ||||
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| Authors | ||||
Amr Kamal Bass   1; Elshimaa Abdelhafez2; Mona El-Zoghbi3; Mamdouh F. A. Mohamed4; Mohamed Badr5; Gamal El-Din A A Abuo-Rahma6
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| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University Menoufia, Egypt | ||||
| 2Associate professor at Medicinal chemistry department Minia university | ||||
| 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt. | ||||
| 4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt | ||||
| 5Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt | ||||
| 6Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt. | ||||
| Abstract | ||||
| Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as natural products and formed the integral backbone of great number of drugs in the market. In particular, 3-cyano-2-oxa-pyridines showed diverse biological and pharmacological activities such as cardiotonic, antimicrobial, antidepressant, and anticancer activity. 3-Cyano-2-oxa-pyridine derivatives have elevated importance for modern medicinal applications especially in cancer therapy. This article shed light on the general chemical synthetic approaches of 3-cyano-2-oxa-pyridines and summarized their various biological activities and pharmacological uses. This article may be helpful in the future to direct attention towards utilization of 3-cyano-2-oxa-pyridine template in the design of new molecules with enhanced biological properties such as PIM1 kinase, tubulin polymerase and survivin inhibitors for cancer therapy or new AMPK activator for diabetes and obesity control or cardiotonic agents. | ||||
| Keywords | ||||
| Cyanopyridines; PIM-1 kinase inhibitors; Survivin inhibitors; AMPK activators | ||||
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