A Histological Study on The Effects of Bisphenol an Administration on The Liver, Spleen and Pancreas of Adult Male Albino Rats and The Possible Protective Role of Lycopene
Mohamed, H., Bastwrous, A. (2021). A Histological Study on The Effects of Bisphenol an Administration on The Liver, Spleen and Pancreas of Adult Male Albino Rats and The Possible Protective Role of Lycopene. EKB Journal Management System, 13(1), 43-61. doi: 10.21608/eajbsd.2021.159174
Hala Z.E. Mohamed; Ashraf E. Bastwrous. "A Histological Study on The Effects of Bisphenol an Administration on The Liver, Spleen and Pancreas of Adult Male Albino Rats and The Possible Protective Role of Lycopene". EKB Journal Management System, 13, 1, 2021, 43-61. doi: 10.21608/eajbsd.2021.159174
Mohamed, H., Bastwrous, A. (2021). 'A Histological Study on The Effects of Bisphenol an Administration on The Liver, Spleen and Pancreas of Adult Male Albino Rats and The Possible Protective Role of Lycopene', EKB Journal Management System, 13(1), pp. 43-61. doi: 10.21608/eajbsd.2021.159174
Mohamed, H., Bastwrous, A. A Histological Study on The Effects of Bisphenol an Administration on The Liver, Spleen and Pancreas of Adult Male Albino Rats and The Possible Protective Role of Lycopene. EKB Journal Management System, 2021; 13(1): 43-61. doi: 10.21608/eajbsd.2021.159174

A Histological Study on The Effects of Bisphenol an Administration on The Liver, Spleen and Pancreas of Adult Male Albino Rats and The Possible Protective Role of Lycopene

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 4, Volume 13, Issue 1, June 2021, Page 43-61  XML PDF (3.59 MB)
Document Type: Original Article
DOI: 10.21608/eajbsd.2021.159174
View on SCiNiTO View on SCiNiTO
Authors
Hala Z.E. Mohamed1; Ashraf E. Bastwrous2
1Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University
2FDepartment of Human Anatomy and Embryology, Faculty of Medicine, Assiut Universityaculty of Medicine, Assiut University
Abstract
 Bisphenol A (BPA) is an endocrine disturbing element liberated through the environment and broadly used all over the world. The purpose of this work was to explore the impacts of BPA on liver, spleen and pancreas of adult male albino rats and the probable protecting role of Lycopene. Thirty adult male albino rats were distributed into three groups; group I (control group) , group II administrated BPA orally (50 mg/kg) for 30 days and group III (BPA+ Lycopene treated group) administered Lycopene (LYC) concomitantly with BPA at a dose of 10 mg/kg. At the end of the experiment, rats of all groups were sacrificed. Liver, spleen and pancreas were extracted, fixed and processed for histologic study. The area % of the collagen fibers in liver, spleen and pancreas was measured in the different groups and statistically analyzed. Structural alterations were discovered in liver, spleen and pancreas of BPA-treated rats including dilated congested blood vessels and vacuolar degeneration of the cells. When Lycopene (LYC) was concomitantly administered with BPA, It produced marked improvement at structural and ultrastructural levels. The morphometric results declared that the area % of the collagen fibers in the liver, spleen and pancreases was considerably increased in the BPA-treated group in comparison to the control group. Meanwhile the area % of the collagen fibers of BPA+ Lycopene treated group was more or less comparable to the control group with no significant difference. It was concluded that LYC has noticeable protective effects versus the damaging effects of BPA.
Keywords
Bisphenol A; liver; Lycopene; pancreas; spleen
Statistics
Article View: 408
PDF Download: 438