Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus
Alzahrani, A., Al-Swat, H., Al Nashar, N., Mohamed, H. (2013). Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus. EKB Journal Management System, 52(1), 630-636. doi: 10.12816/0000600
Ali K Alzahrani; Humaid Al-Swat; Nihad A Al Nashar; Hala A Mohamed. "Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus". EKB Journal Management System, 52, 1, 2013, 630-636. doi: 10.12816/0000600
Alzahrani, A., Al-Swat, H., Al Nashar, N., Mohamed, H. (2013). 'Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus', EKB Journal Management System, 52(1), pp. 630-636. doi: 10.12816/0000600
Alzahrani, A., Al-Swat, H., Al Nashar, N., Mohamed, H. Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus. EKB Journal Management System, 2013; 52(1): 630-636. doi: 10.12816/0000600

Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus

The Egyptian Journal of Hospital Medicine
Article 16, Volume 52, Issue 1, July 2013, Page 630-636  XML PDF (312.41 K)
Document Type: Original Article
DOI: 10.12816/0000600
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Authors
Ali K Alzahrani1; Humaid Al-Swat2; Nihad A Al Nashar3; Hala A Mohamed3
1Department of Pediatrics, Taif University
2Department of Pediatrics and Neonatology, King Abdul Aziz Specialist Hospital
3Department of Pathology, Taif University
Abstract
Background and aim of the work: Genetic and environmental factors may play a role in the etiology of type 1diabetes (T1D) but a well-accepted view is that autoimmunity is the predominant effector.The aim of this study is to investigate the profile and the relationships between interleukin (IL, CXCL) -8 and nitric oxide metabolite (NOx) in T1D and to reveal their possible role in the development and progression of the disease and its complications.  
Material and method:Twenty children with Type 1 diabetes (T1D) were enrolled for the study and compared to twenty healthy age and gender matched non-diabetic controls.
Results:The data revealed that children with T1D established high glycated hemoglobin (HbA1c %) values versus the control group (P<0.0001). Significantly higher serum CXCL-8 concentration (23.54±11.92pg/ml) was detected in T1D children versus the control group(5.69±1.67pg/ml). 0n the other hand, serum nitric acid metabolite (NOx) showed a significant reduction in the T1D children (2.38±1.14 mmol/l) compared to the control group (4.63±1.2 mmol/l). Correlation analysis showed positive correlation between CXCL-8 with duration of the diabetes and with HbA1c.
Conclusion: It could be concluded that CXCL-8 and NO may play important roles in the pathophysiology and progression of T1D with increased possibility to develop premature atherosclerosis which should be considered in the development of new strategies for monitoring the disease as well as for developing effective preventive and therapeutic interventions.
 
 


Keywords
Pediatric T1D; CXCL-8; NOx; endothelial dysfunction; premature atherosclerosis
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