Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2 | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 31, Volume 83, Issue 1, April 2021, Page 995-1001 PDF (782.97 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.160044 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Maher Borai Mohammad  1; Ahmad Soliman Sallam1; Abeer Abdalla Fekry1; Mohammad Ibrahim Amin2
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| 1Departments of 1Clinical Pathology Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Departments of Cardiology, Faculty of Medicine, Zagazig University, Egypt. | ||||
| Abstract | ||||
| Monocyte chemoattractant protein-1 (MCP-1) is the first discovered and most extensively studied chemotactic cytokines (CC = chemokine). Many studies on its role in the etiologies of obesity- and diabetes-related diseases have been increased exponentially during the past two decades. MCP-1, a chemokine involved in monocyte chemotaxis can be consistently found at high levels in the patients with type 2 diabetes mellitus. MCP1 may be an early predictor of complications of diabetes. Objective: Assessment of the levels of MCP-1 and other biochemical markers in diabetic subjects compared to a healthy group, which in turn can be beneficial to clarify the correlations of MCP-1 levels in diabetes mellitus with other clinical and biochemical parameters. Patients and methods: Eighty-one participants including both male and female, of cross-matched ages ranging between 30 – 60 years old were included in this study. They were divided into three equal groups: group I (control group), group II (recently diagnosed T2DM) and group III (old diagnosed T2DM more than 10 years). Results: The highest level of MCP-1 was found in the old diagnosed diabetic group while the lowest level was found in the non-diabetic control group. The LSD statistical analysis showed there was significant difference between all groups of the study. Our results showed that serum MCP-1 was elevated in cases of the group 3 (old diagnosed diabetic patients) who were suffering from diabetic nephropathy (9/27), diabetic retinopathy (9/27) and the last 9/27 were suffering of neuropathy. Conclusion: The MCP-1 level is increased in type 2 Diabetic patients and significantly increased with the progression of diabetes complications as diabetic retinopathy, diabetic nephropathy and diabetic neuropathy. | ||||
| Keywords | ||||
| MCP-1; T2DM | ||||
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