“Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study"
abdallah, S., kandil, M., El Rafie, D. (2021). “Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study". EKB Journal Management System, 67(2), 1371-1383. doi: 10.21608/edj.2021.55450.1430
shaimaa abdallah; Mohamed kandil; Dina El Rafie. "“Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study"". EKB Journal Management System, 67, 2, 2021, 1371-1383. doi: 10.21608/edj.2021.55450.1430
abdallah, S., kandil, M., El Rafie, D. (2021). '“Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study"', EKB Journal Management System, 67(2), pp. 1371-1383. doi: 10.21608/edj.2021.55450.1430
abdallah, S., kandil, M., El Rafie, D. “Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study". EKB Journal Management System, 2021; 67(2): 1371-1383. doi: 10.21608/edj.2021.55450.1430

“Release characterization and biological effect of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives”: "An in Vitro Study"

Egyptian Dental Journal
Article 4, Volume 67, Issue 2 - Serial Number 4, April 2021, Page 1371-1383  XML PDF (1.24 MB)
Document Type: Original Article
DOI: 10.21608/edj.2021.55450.1430
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Authors
shaimaa abdallah email orcid 1; Mohamed kandilorcid 2; Dina El Rafieorcid 3
1BDS, Researcher at biomaterial , Department of Biomaterials, Faculty of Dentistry, Ain- Shams University, organization of African unity St, El-Qobba Bridge, Al Waili, Cairo Governorate, Egypt
2Lecturer of Dental Biomaterials, Department of Biomaterials, Faculty of Dentistry, Ain- Shams University, organization of African unity St, El-Qobba Bridge, Al Waili, Cairo Governorate, Egypt.
3Associate professor of Dental Biomaterials, Biomaterials Department, , Faculty of Dentistry, Ain- Shams University, organization of African unity St, El-Qobba Bridge, Al Waili, Cairo Governorate, Egypt.
Abstract
Abstract
Aims: To evaluate the effect of adding two different chlorohexidine derivatives; chlorhexidine hexametaphosphate and chlorhexidine digluconate to glass ionomer at three different concentrations (0.25%, 0.75%and 1.5%) regarding the antibacterial effect, chlorhexidine release and fluoride release.
Methods:
A total of 405 specimens were prepared and tested after 7 days, 3 months and 6 months of storage in distilled water (n=5).For testing antibacterial effect, chlorhexidine release and fluoride release, the mix was packed in a ready-made Split Teflon molds to obtain disc-shaped specimen with dimensions 10 mm in diameter and 2 mm thickness according to ISO standardizations. One-way ANOVA and One-way repeated measure ANOVA test were used for statistical analysis of data.
Results: The incorporation of chlorhexidine into ChemFil Superior glass ionomer cement in both derivatives has high significance ability to provide a long-term antimicrobial effect on Streptococcus mutans and Lactobacillius acidophilus. The chlorhexidine release was increased by adding chlorhexidine in both derivatives to GIC than the unmodified Glass-ionomer cement for study duration. However, the fluoride release was decreased in the modified specimens than the original one.
Conclusions: addition of chlorhexidine enhanced the antibacterial effect of the glass ionomer and chlorhexidine release. However, fluoride release was reduced than original
Keywords
superior chemifil glass ionomer cement; chlorhexidine hexametaphosphate; chlorhexidine digluconate; antibacterial effect fluoride release
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