The efficiency of Trifolium pratense seed extract against the deleterious effects caused by nicotine in the liver of rat
EL Sayyad, H., Mostafa, A., Kamal, Z. (2009). The efficiency of Trifolium pratense seed extract against the deleterious effects caused by nicotine in the liver of rat. EKB Journal Management System, 1(1), 7-27. doi: 10.21608/eajbsz.2009.16018
Hasan EL Sayyad; Amna M. Mostafa; Zainab Kamal. "The efficiency of Trifolium pratense seed extract against the deleterious effects caused by nicotine in the liver of rat". EKB Journal Management System, 1, 1, 2009, 7-27. doi: 10.21608/eajbsz.2009.16018
EL Sayyad, H., Mostafa, A., Kamal, Z. (2009). 'The efficiency of Trifolium pratense seed extract against the deleterious effects caused by nicotine in the liver of rat', EKB Journal Management System, 1(1), pp. 7-27. doi: 10.21608/eajbsz.2009.16018
EL Sayyad, H., Mostafa, A., Kamal, Z. The efficiency of Trifolium pratense seed extract against the deleterious effects caused by nicotine in the liver of rat. EKB Journal Management System, 2009; 1(1): 7-27. doi: 10.21608/eajbsz.2009.16018

The efficiency of Trifolium pratense seed extract against the deleterious effects caused by nicotine in the liver of rat

Egyptian Academic Journal of Biological Sciences, B. Zoology
Article 2, Volume 1, Issue 1, December 2009, Page 7-27  XML PDF (12.1 K)
Document Type: Original Article
DOI: 10.21608/eajbsz.2009.16018
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Authors
Hasan EL Sayyad1; Amna M. Mostafa2; Zainab Kamal2
1Department of Zoology, Faculty of Science, EL Mansora University
2Department of Zoology, Faculty of Science, South Valley University
Abstract
The aim of this study was to determine the adverse effects of maternal nicotine treatment during pregnancy and on rat liver of newborns. Also to determine a protective effect of Trifolium Pratenseseed extract against the deleterious effects of nicotine. All groups were treated from the 6th day of gestation till parturition. The dams and their newborns were sacrificed and piece of liver from each subjected to the histological studies. The morphological findings of the newborns revealed marked signs of retardation in growth with malformations including superficial haematoma, shortened neck region, kinky tail, uni-and bilateral deformity of both fore and hind limbs and abnormal skin. The histopathological studies on the liver of the maternal nicotine treated and their newborns revealed disruption of hepatic cords arrangement. Blood sinusoids were dilated. The hepatic tissue exhibited inflammatory cells with signs of early cellular granulomatous lesions. Some hepatocytes obliterated and others with karyolysis nuclei. Kupffer cells become hypertrophied and dispersed throughout the hepatic cords. Fatty vacuoles and infiltrations were detected in many of the hepatocytes.
The magnitude of these changes was dose dependent. TPSE supplementation was found to ameliorate an prevent the adverse effects of maternal nicotine treatment morphologically and histologically.     
Keywords
Trifolium Pratense seed (TPSE) – Liver – Mother Rat – Nicotine – Newborns
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