Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers
Attia, T., El-Hanbaly, S., elhoseiny, E. (2021). Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers. EKB Journal Management System, 3(1), 86-92. doi: 10.21608/jcvr.2021.160256
Taha Attia; Saber El-Hanbaly; eman elhoseiny. "Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers". EKB Journal Management System, 3, 1, 2021, 86-92. doi: 10.21608/jcvr.2021.160256
Attia, T., El-Hanbaly, S., elhoseiny, E. (2021). 'Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers', EKB Journal Management System, 3(1), pp. 86-92. doi: 10.21608/jcvr.2021.160256
Attia, T., El-Hanbaly, S., elhoseiny, E. Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers. EKB Journal Management System, 2021; 3(1): 86-92. doi: 10.21608/jcvr.2021.160256

Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers

Journal of Current Veterinary Research
Article 10, Volume 3, Issue 1, April 2021, Page 86-92  XML PDF (323.35 K)
Document Type: Original Article
DOI: 10.21608/jcvr.2021.160256
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Authors
Taha Attia1; Saber El-Hanbaly1; eman elhoseiny email orcid 2
1Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City.
2pharmacology department, faculty of veterinary medicine, universty of sadat city
Abstract
The Effect of toltrazuril on the disposition kinetics and bioavailability of thiamphenicol following a single intravenous (IV) and oral administrations in broiler chickens at a dose of 30 mg/kg body weight was investigated. The serum thiamphenicol concentration was detected by high performance liquid chromatography. After IV injection, thiamphenicol serum concentration was best to be described by a two-compartment open model. Toltrazuril pretreatment was resulted in a significance increase in Vdss and Cltot (3.51±0.1and 0.38±0.005 L/kg, respectively) of thiamphenicol compared with thiamphenicol administered alone (2.31±0.1 and 0.31±0.006L /kg, respectively).The elimination half-life and the mean residence time of thiamphenicol were 4.58±0.2 and 2.44±0.1, 5.72±0.2 and 2.25±0.1h., in control and toltrazuril pretreated chickens, respectively. Following oral dosing, the maximum serum concentration was 14.58±0.1 and 11.88±0.04 μg/ml reached at 3.64±0.01 and 3.56±0.01h, in control and toltrazuril pretreated chickens, respectively. Oral bioavailability was found to be 117.79± 1.2 and114.85 ±0 .7 % in control and toltrazuril pretreated chickens, respectively. It was concluded that the pretreatment of toltrazuril with thiamphenicol in broilers altered the pharmacokinetic profile of thiamphenicol.

Keywords
Toltrazuril; Thiamphenicol - Broilers-disposition kinetics
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