Resistin; a physiological overview | ||||
| Zagazig Veterinary Journal | ||||
| Article 7, Volume 49, Issue 1, March 2021, Page 78-91 PDF (670.32 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/zvjz.2021.62555.1130 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mona bakry   1; Noura E. Abd El-Hameed1; Reda M. Abd El-Aziz2; Mohamed M. Z. Hamada3
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| 1Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Egypt | ||||
| 2Physiology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt | ||||
| 3Department of Physiology, Faculty of Veterinary Medicine, Zagazig University | ||||
| Abstract | ||||
| Resistin is a novel peptide which is known to be an adipocyte-derived cytokine. It belongs to resistin like molecule family. It was revealed that resistin is an important link between obesity, insulin resistance and type 2 Diabetes Mellitus. After that, several investigations showed the important physiological activities of resistin apart from its role in insulin resistance and diabetes in many pathological conditions as cardiovascular diseases (as coronary thrombosis), malignancy, endothelial dysfunction, hypertension, thrombosis, angiogenesis, inflammation, asthma, autoimmune disease, atherosclerosis and chronic kidney disease. Moreover, several studies have underlined it’s participation in reproductive functions. It is well known that resistin expression is recorded in murine white adipose tissue but in human its expression is noticed in monocytes and macrophages. The mechanism of action, receptors and signaling pathways are beginning to be distinguished. In the present review, the present data concerning the discovery, structure, tissue distribution and functional role of resistin is summarized. | ||||
| Keywords | ||||
| Resistin; Resistin like molecules family; inflammatory zone3; adipokines | ||||
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