Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum | ||||
| Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
| Article 7, Volume 4, Issue 2, April 2021, Page 107-110 PDF (370.08 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jabps.2021.62964.1120 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mostafa A. Fouad   1; sabry Zidan2; Mohamed A. A. Orabi2; Reda A. Abdelhamid2; Abdallah Allian3; katsuyoshi matsunmai4
| ||||
| 1Pharmacognosy Department, faculty of Pharmacy, Minia University, Minia 61519, Egypt | ||||
| 2Departement of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt | ||||
| 3Departement of Zoolgy, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, Egypt | ||||
| 4Departement of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan | ||||
| Abstract | ||||
| The aim of the present study is the evaluation of the in-vitro cytotoxicity and antileishmanial activities of a methanolic extract and its different fractions of the soft coral Sarcophyton spongiosum collected from the Egyptian Red Sea against three cancer cell lines, A549, HepG2, and MCF-7, and a protozoan, Leishmania Major, by the MTT assay protocol. The dichloromethane fraction exhibited significant anti-Leishmania major (IC50 28.1 ± 1.2 µg/mL) and cytotoxic activities against MCF-7 cell line IC50 (31.5 ± 1.1 µg/mL). The ethyl acetate fraction showed promising cytotoxicity against A549 and HepG2 cell lines (IC50 13.4 ± 1.2 and 11.6 ± 1.9 µg/mL, respectively). A preliminary chemical screening of the total methanolic extract indicated of the presence of sterols and diterpenes. | ||||
| Keywords | ||||
| Soft corals; Sarcophyton spongiosum; cytotoxicity; anti-Leishmania; MTT assay | ||||
|
Statistics Article View: 304 PDF Download: 484 |
||||
